Prof. Dr. Ana Rita Brochado
Kontakt:
Tel.: +49 931 31-88860
E-mail: anarita.brochado@uni-wuerzburg.de
Raum: D222
Forschungsprojekt
Academic Career
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Jan 2019, Group leader, Chair of Microbiology, University of Würzburg
- 2012 - 2018, Postdoc, European Molecular Biology Laboratory (EMBL), Heidelberg
- 2012, PhD in Biotechnology, Technical University of Denmark, Lyngby, Denmark
- 2007, MSc in Biological Engineering, Instituto Superior Técnico, Lisbon Portugal
- Brenzinger S, Airoldi M, Ogunleye AJ, Jugovic K, Amstalden MK, Brochado AR. The Vibrio cholerae CBASS phage defence system modulates resistance and killing by antifolate antibiotics. Nat Microbiol. 2024 Jan;9(1):251-262. doi: 10.1038/s41564-023-01556-y.
- Klünemann M, Andrejev S, Blasche S, Mateus A, Phapale P, Devendran S, Vappiani J, Simon B, Scott TA, Kafkia E, Konstantinidis D, Zirngibl K, Mastrorilli E, Banzhaf M, Mackmull MT, Hövelmann F, Nesme L, Brochado AR, Maier L, Bock T, Periwal V, Kumar M, Kim Y, Tramontano M, Schultz C, Beck M, Hennig J, Zimmermann M, Sévin DC, Cabreiro F, Savitski MM, Bork P, Typas A, Patil KR. Bioaccumulation of therapeutic drugs by human gut bacteria. Nature. 2021 Sep;597(7877):533-538. doi: 10.1038/s41586-021-03891-8.
- Graw J, Engelhardt H, Küsel K, Kruck D, Tinnefeld P, Sander J, Robatzek S, Schäberle TF, Aichane K, Brochado AR, Gerlach D. Journal Club. Biospektrum (Heidelb). 2021;27(4):400-405. doi: 10.1007/s12268-021-1601-9.
- Domenech A, Brochado AR, Sender V, Hentrich K, Henriques-Normark B, Typas A, Veening JW. Proton Motive Force Disruptors Block Bacterial Competence and Horizontal Gene Transfer. Cell Host Microbe. 2020 Feb 22. pii: S1931-3128(20)30073-1. doi: 10.1016/j.chom.2020.02.002.
- Brochado AR, Telzerow A, Bobonis J, Banzhaf M, Mateus A, Selkrig J, Huth E, Bassler S, Zamarreño Beas J, Zietek M,Ng N, Foerster S, Ezraty B, Py B, Barras F, Savitski MM, Bork P, Göttig S and Typas A. “Species-specific activity of antibacterial drug combinations“. Nature 2018. doi: 10.1038/s41586-018-0278-9.
- Maier L, Pruteanu M, Kuhn M, Zeller G, Telzerow A, Anderson EE, Brochado AR, Fernandez KC, Dose H, Mori H, Patil KR, Bork P, Typas A. “Extensive impact of non-antibiotic drugs on human gut bacteria”. Nature 2018. 555(7698) p.634-628. doi: 10.1038/nature25979.
- Ezraty B, Vergnes A, Banzhaf M, Duverger Y, Huguenot A, Brochado AR, et al. “Fe-S Cluster Biosynthesis Controls Uptake of Aminoglycosides in a ROS-Less Death Pathway”. Science 2013. 340(6140) p.1583-1587. doi: 10.1126/science.1238328.
- Brochado AR and Typas A. “High-throughput approaches to understanding gene function and mapping network architecture in bacteria”. Current Opinion in Microbiology 2013. 16(2) p.199-206. doi: 10.1016/j.mib.2013.01.008.
- Brochado AR and Patil KR. “Overexpression of O-methyltransferase leads to improved vanillin production in baker's yeast only when complemented with model-guided network engineering”. Biotechnology and Bioengineering 2013. 110(2) p656-659. doi: 10.1007/978-1-4939-0563-8_17.
- Brochado AR, Andrejev S, Maranas CD and Patil KR. “Impact of Stoichiometry Representation on Simulation of Genotype-Phenotype Relationships in Metabolic Networks”. PloS Computational Biology 2012. doi: 10.1371/journal.pcbi.1002758.
- Brochado AR, Matos C, Møller BL, Hansen J, Mortensen UH, Patil KR. “Improved vanillin production in baker’s yeast through in silico design”. Microbial Cell Factories 2010. 9:84. doi: 10.1186/1475-2859-9-84.
- Brochado AR & Patil KR. "Model-guided identification of gene deletion targets for metabolic engineering in Saccharomyces cerevisiae”. Yeast Metabolic Engineering: Methods and Protocols, Springer 2014, 281-291. doi: 10.1007/978-1-4939-0563-8_17.
