Publications
Publication List Prof. Thomas Müller
- [ 2024 ]
- [ 2023 ]
- [ 2022 ]
- [ 2021 ]
- [ 2020 ]
- [ 2019 ]
- [ 2018 ]
- [ 2017 ]
- [ 2016 ]
- [ 2015 ]
- [ 2014 ]
- [ 2013 ]
- [ 2012 ]
- [ 2011 ]
- [ 2010 ]
- [ 2009 ]
2024[ to top ]
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‘Lessons on protein structure from interleukin-4: All disulfides are not created equal’, Proteins, 92(2), 219–235, available: https://doi.org/10.1002/prot.26611.(2024)
2023[ to top ]
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‘Design of Glycoengineered IL-4 Antagonists Employing Chemical and Biosynthetic Glycosylation’, ACS omega, 8(28), 24841–24852, available: https://doi.org/10.1021/acsomega.3c00726.(2023)
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‘Insights into receptor structure and dynamics at the surface of living cells’, Nature Communications, 14(1596), 15, available: https://doi.org/doi: 10.1038/s41467-023-37284-4.(2023)
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‘TPC1 vacuole SV channel gains further shape – voltage priming of calcium-dependent gating’, Trends in Plant Science, 28(6), 673–684, available: https://doi.org/https://doi.org/10.1016/j.tplants.2023.01.001.(2023)
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‘Molecular forms of BMP15 and GDF9 in mammalian species that differ in litter size’, Scientific reports, 13(1), 22428–22428, available: https://doi.org/10.1038/s41598-023-49852-1.(2023)
2022[ to top ]
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‘Site-Directed Immobilization of an Engineered Bone Morphogenetic Protein 2 ({BMP}2) Variant to Collagen-Based Microspheres Induces Bone Formation In Vivo’, International Journal of Molecular Sciences, 23(7), 3928, available: https://doi.org/10.3390/ijms23073928.(2022)
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‘A nonfunctional copy of the salmonid sex-determining gene (sdY) is responsible for the “apparent” XY females in Chinook salmon, Oncorhynchus tshawytscha’, G3 (Bethesda, Md.), 12(2), jkab451-, available: https://doi.org/10.1093/g3journal/jkab451.(2022)
2021[ to top ]
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‘Acidosis-induced activation of anion channel {SLAH}3 in the flooding-related stress response of Arabidopsis’, Current Biology, 31(16), 3575–3585.e9, available: https://doi.org/10.1016/j.cub.2021.06.018.(2021)
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‘A supernumerary “B-sex” chromosome drives male sex determination in the Pachón cavefish, Astyanax mexicanus’, Current Biology, 31(21), 4800–4809.e9, available: https://doi.org/https://doi.org/10.1016/j.cub.2021.08.030.(2021)
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‘Optimized expression and purification of a soluble BMP2 variant based on in-silico design’, Protein Expression and Purification, 186, 105918, available: https://doi.org/https://doi.org/10.1016/j.pep.2021.105918.(2021)
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‘Acidosis-induced activation of anion channel SLAH3 in the flooding-related stress response of Arabidopsis’, Current Biology, available: https://doi.org/https://doi.org/10.1016/j.cub.2021.06.018.(2021)
2020[ to top ]
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‘An Activating Deletion Variant in the Submembrane Region of Natriuretic Peptide Receptor-B Causes Tall Stature’, J Clin Endocrinol Metab, 105(7), available: https://doi.org/10.1210/clinem/dgaa190.(2020)
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‘Stabilization of desmoglein-2 binding rescues arrhythmia in arrhythmogenic cardiomyopathy’, {JCI} Insight, 5(9), available: https://doi.org/10.1172/jci.insight.130141.(2020)
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‘Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex’, Proceedins of the National Academy of Sciences of the United States of America, 117(27), 15620–15631, available: https://doi.org/https://doi.org/10.1073/pnas.2000561117.(2020)
2019[ to top ]
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‘Rat Organic Cation Transporter 1 Contains Three Binding Sites for Substrate 1-Methyl-4-phenylpyridinium per Monomer’, Mol Pharmacol, 95(2), 169–182, available: https://doi.org/10.1124/mol.118.113498.(2019)
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‘Specification of BMP Signaling’, Cells, 8(12), available: https://doi.org/10.3390/cells8121579.(2019)
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‘Structural Basis of Interleukin-5 Inhibition by the Small Cyclic Peptide AF17121’, J Mol Biol, 431(4), 714–731, available: https://doi.org/10.1016/j.jmb.2018.11.029.(2019)
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‘POPDC3 Gene Variants Associate with a New Form of Limb Girdle Muscular Dystrophy’, Ann Neurol, 86(6), 832–843, available: https://doi.org/10.1002/ana.25620.(2019)
2018[ to top ]
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‘The unusual rainbow trout sex determination gene hijacked the canonical vertebrate gonadal differentiation pathway’, Proc Natl Acad Sci U S A, available: https://doi.org/10.1073/pnas.1803826115.(2018)
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‘Bioresponsive release of insulin-like growth factor-I from its PEGylated conjugate’, J Control Release, 279, 17–28, available: https://doi.org/10.1016/j.jconrel.2018.04.009.(2018)
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‘Structure and Function of TPC1 Vacuole SV Channel Gains Shape’, Mol Plant, available: https://doi.org/10.1016/j.molp.2018.03.017.(2018)
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‘Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry’, J Vis Exp, (133), available: https://doi.org/10.3791/56616.(2018)
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‘Collagen I derived recombinant protein microspheres as novel delivery vehicles for bone morphogenetic protein-2’, Mater Sci Eng C Mater Biol Appl, 84, 271–280, available: https://doi.org/10.1016/j.msec.2017.11.031.(2018)
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‘Assay Conditions Influence Affinities of Rat Organic Cation Transporter 1: Analysis of Mutagenesis in the Modeled Outward-facing Cleft by Measuring Effects of Substrates and Inhibitors on Initial Uptake’, Mol Pharmacol, available: https://doi.org/10.1124/mol.117.110767.(2018)
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‘TGF-β family co-receptor function and signaling’, Acta Biochim Biophys Sin (Shanghai), 50(1), 12–36, available: https://doi.org/10.1093/abbs/gmx126.(2018)
2017[ to top ]
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‘The anti-myeloma activity of bone morphogenetic protein 2 predominantly relies on the induction of growth arrest and is apoptosis-independent’, PLoS One, 12(10), available: https://doi.org/10.1371/journal.pone.0185720.(2017)
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‘Low doses of cholera toxin and its mediator cAMP induce CTLA-2 secretion by dendritic cells to enhance regulatory T cell conversion’, PLoS One, 12(7), available: https://doi.org/10.1371/journal.pone.0178114.(2017)
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‘BMP15 Mutations Associated With Primary Ovarian Insufficiency Reduce Expression, Activity, or Synergy With GDF9’, J Clin Endocrinol Metab, 102(3), 1009–1019.(2017)
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‘Design and validation of a disease network of inflammatory processes in the NSG-UC mouse model’, J Transl Med, 15(1), 265–265, available: https://doi.org/10.1186/s12967-017-1368-4.(2017)
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‘Site-Directed Immobilization of BMP-2: Two Approaches for the Production of Innovative Osteoinductive Scaffolds’, Biomacromolecules, 18(3), 695–708, available: https://doi.org/10.1021/acs.biomac.6b01407.(2017)
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‘Utilizing BMP-2 muteins for treatment of multiple myeloma’, PLOS ONE, 12(5), 1–18, available: https://doi.org/10.1371/journal.pone.0174884.(2017)
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‘Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments’, Nat Commun, 8, 15976–15976, available: https://doi.org/10.1038/ncomms15976.(2017)
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‘Control of basal jasmonate signalling and defence through modulation of intracellular cation flux capacity’, New Phytol, 216(4), 1161–1169, available: https://doi.org/10.1111/nph.14754.(2017)
2016[ to top ]
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‘Gating of the two-pore cation channel AtTPC1 in the plant vacuole is based on a single voltage-sensing domain’, Plant Biol (Stuttg), 18(5), 750–60, available: https://doi.org/10.1111/plb.12478.(2016)
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‘Structural Biology and Evolution of the TGF-beta Family’, Cold Spring Harb Perspect Biol, 8(12), available: https://doi.org/10.1101/cshperspect.a022103.(2016)
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‘The sclerostin-neutralizing antibody AbD09097 recognizes an epitope adjacent to sclerostin’s binding site for the Wnt co-receptor LRP6’, Open Biol, 6(8), available: https://doi.org/10.1098/rsob.160120.(2016)
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‘The Venus Flytrap Dionaea muscipula Counts Prey-Induced Action Potentials to Induce Sodium Uptake’, Curr Biol, 26(3), 286–95, available: https://doi.org/10.1016/j.cub.2015.11.057.(2016)
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‘Structural insights into BMP receptors: Specificity, activation and inhibition’, Cytokine Growth Factor Rev, 27, 13–34, available: https://doi.org/10.1016/j.cytogfr.2015.11.005.(2016)
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‘POPDC1(S201F) causes muscular dystrophy and arrhythmia by affecting protein trafficking’, J Clin Invest, 126(1), 239–53, available: https://doi.org/10.1172/JCI79562.(2016)
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‘A mouse model for ulcerative colitis based on NOD-scid IL2R gammanull mice reconstituted with peripheral blood mononuclear cells from affected individuals’, Dis Model Mech, 9(9), 985–97, available: https://doi.org/10.1242/dmm.025452.(2016)
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‘Protein RS1 (RSC1A1) Downregulates the Exocytotic Pathway of Glucose Transporter SGLT1 at Low Intracellular Glucose via Inhibition of Ornithine Decarboxylase’, Mol Pharmacol, 90(5), 508–521, available: https://doi.org/10.1124/mol.116.104521.(2016)
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‘Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion’, J Exp Med, 213(9), 1881–900, available: https://doi.org/10.1084/jem.20151563.(2016)
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‘Interleukin-4-Clicked Surfaces Drive M2 Macrophage Polarization’, Chembiochem, 17(22), 2123–2128, available: https://doi.org/10.1002/cbic.201600480.(2016)
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‘Venus Flytrap HKT1-Type Channel Provides for Prey Sodium Uptake into Carnivorous Plant Without Conflicting with Electrical Excitability’, Mol Plant, 9(3), 428–36, available: https://doi.org/10.1016/j.molp.2015.09.017.(2016)
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‘The Nonspecific Lipid Transfer Protein AtLtpI-4 Is Involved in Suberin Formation of Arabidopsis thaliana Crown Galls’, Plant Physiol, 172(3), 1911–1927, available: https://doi.org/10.1104/pp.16.01486.(2016)
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‘Biological activity and in vivo half-life of pro-activin A in male rats’, Mol Cell Endocrinol, 422, 84–92, available: https://doi.org/10.1016/j.mce.2015.12.007.(2016)
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‘Dynamin-dependent endocytosis of Bone Morphogenetic Protein2 (BMP2) and its receptors is dispensable for the initiation of Smad signaling’, Int J Biochem Cell Biol, 76, 51–63, available: https://doi.org/10.1016/j.biocel.2016.04.010.(2016)
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‘Proteomic Analysis of Excretory-Secretory Products of Mesocestoides corti Metacestodes Reveals Potential Suppressors of Dendritic Cell Functions’, PLoS Negl Trop Dis, 10(10), e0005061, available: https://doi.org/10.1371/journal.pntd.0005061.(2016)
2015[ to top ]
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‘Mechanisms of BMP-Receptor Interaction and Activation’, Vitam Horm, 99, 1–61, available: https://doi.org/10.1016/bs.vh.2015.06.003.(2015)
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‘RGM co-receptors add complexity to BMP signaling’, Nat Struct Mol Biol, 22(6), 439–40, available: https://doi.org/10.1038/nsmb.3037.(2015)
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‘Modifications of human growth differentiation factor 9 to improve the generation of embryos from low competence oocytes’, Mol Endocrinol, 29(1), 40–52, available: https://doi.org/10.1210/me.2014-1173.(2015)
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‘The hypervariable region 4 (HV4) and position 93 of the alpha chain modulate CD1d-glycolipid binding of iNKT TCRs’, Eur J Immunol, 45(7), 2122–33, available: https://doi.org/10.1002/eji.201545534.(2015)
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‘A hypomorphic BMPR1B mutation causes du Pan acromesomelic dysplasia’, Orphanet J Rare Dis, 10, 84, available: https://doi.org/10.1186/s13023-015-0299-5.(2015)
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‘Cumulin, an Oocyte-secreted Heterodimer of the Transforming Growth Factor-beta Family, Is a Potent Activator of Granulosa Cells and Improves Oocyte Quality’, J Biol Chem, 290(39), 24007–20, available: https://doi.org/10.1074/jbc.M115.671487.(2015)
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‘Crystallization and preliminary X-ray crystallographic analysis of the sclerostin-neutralizing Fab AbD09097’, Acta Crystallogr F Struct Biol Commun, 71(Pt 4), 388–92, available: https://doi.org/10.1107/S2053230X1500360X.(2015)
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‘GDF-5 can act as a context-dependent BMP-2 antagonist’, BMC Biol, 13, 77, available: https://doi.org/10.1186/s12915-015-0183-8.(2015)
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‘Venus Flytrap HKT1-Type Channel Provides for Prey Sodium Uptake into Carnivorous Plant Without Conflicting with Electrical Excitability’, Mol Plant, available: https://doi.org/10.1016/j.molp.2015.09.017.(2015)
2014[ to top ]
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‘A Single-Pore Residue Renders the Arabidopsis Root Anion Channel SLAH2 Highly Nitrate Selective’, Plant Cell, 26(6), 2554–2567, available: https://doi.org/10.1105/tpc.114.125849.(2014)
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‘IL-4 analogues with site-specific chemical modification at position 121 inhibit IL-4 and IL-13 biological activities’, Bioconjugate chemistry, 25(1), 52–62, available: https://doi.org/10.1021/bc400307k.(2014)
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‘Does the haplotype Met408-Del420, which was apparently predictive for imatinib efficacy, really exist and how strongly may it affect OCT1 activity?’, Blood, 123(9), 1427–9, available: https://doi.org/10.1182/blood-2013-11-535864.(2014)
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‘Homozygous missense and nonsense mutations in BMPR1B cause acromesomelic chondrodysplasia-type Grebe’, European journal of human genetics : EJHG, 22(6), 726–33, available: https://doi.org/10.1038/ejhg.2013.222.(2014)
2013[ to top ]
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‘Mutational analysis of sclerostin shows importance of the flexible loop and the cystine-knot for wnt-signaling inhibition’, PLoS One, 8(11), e81710, available: https://doi.org/10.1371/journal.pone.0081710.(2013)
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‘Identification of a Novel TGF-beta-Binding Site in the Zona Pellucida C-terminal (ZP-C) Domain of TGF-beta-Receptor-3 (TGFR-3)’, PLoS One, 8(6), e67214, available: https://doi.org/10.1371/journal.pone.0067214.(2013)
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‘Oxazolone and ethanol induce colitis in non-obese diabetic-severe combined immunodeficiency interleukin-2Rgamma(null) mice engrafted with human peripheral blood mononuclear cells’, Clinical and experimental immunology, 172(2), 349–62, available: https://doi.org/10.1111/cei.12057.(2013)
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‘Induction of oxazolone-mediated features of atopic dermatitis in NOD-scid IL2Rgamma(null) mice engrafted with human peripheral blood mononuclear cells’, Disease models & mechanisms, 6(1), 125–34, available: https://doi.org/10.1242/dmm.009167.(2013)
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‘Anti-Sclerostin Antibody Inhibits Internalization of Sclerostin and Sclerostin-Mediated Antagonism of Wnt/LRP6 Signaling’, PLoS One, 8(4), e62295, available: https://doi.org/10.1371/journal.pone.0062295.(2013)
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‘Hyperactivation of constitutively dimerized oncogenic EGF receptors by autocrine loops’, Oncogene, 32(19), 2403–11, available: https://doi.org/10.1038/onc.2012.267.(2013)
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‘NOD-scid IL2R gammanull mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways’, Journal of translational medicine, 11, 4, available: https://doi.org/10.1186/1479-5876-11-4.(2013)
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‘The clip-segment of the von Willebrand domain 1 of the BMP modulator protein Crossveinless 2 is preformed’, Molecules, 18(10), 11658–82, available: https://doi.org/10.3390/molecules181011658.(2013)
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‘Growth differentiation factor 9:bone morphogenetic protein 15 (GDF9:BMP15) synergism and protein heterodimerization’, Proceedings of the National Academy of Sciences of the United States of America, 110(25), E2257, available: https://doi.org/10.1073/pnas.1303459110.(2013)
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‘An activating mutation in the kinase homology domain of the natriuretic peptide receptor-2 causes extremely tall stature without skeletal deformities’, The Journal of clinical endocrinology and metabolism, 98(12), E1988–98, available: https://doi.org/10.1210/jc.2013-2358.(2013)
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‘Tyr728 in the kinase domain of the murine kinase suppressor of RAS 1 regulates binding and activation of the mitogen-activated protein kinase kinase’, The Journal of biological chemistry, 288(49), 35237–52, available: https://doi.org/10.1074/jbc.M113.490235.(2013)
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‘The Dionaea muscipula Ammonium Channel DmAMT1 Provides NH4(+) Uptake Associated with Venus Flytrap’s Prey Digestion’, Current biology : CB, 23(17), 1649–57, available: https://doi.org/10.1016/j.cub.2013.07.028.(2013)
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‘Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3’, Nature medicine, 19(7), 809–10, available: https://doi.org/10.1038/nm.3080.(2013)
2012[ to top ]
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‘Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice’, J Clin Invest, 122(3), 1119–30, available: https://doi.org/10.1172/JCI59410.(2012)
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‘Missense mutations in GDF5 signaling: molecular mechanisms behind skeletal malformation’, in Cooper, D. and Chen, J.-M., eds., Gene Mutation, Rijeka, Croatia: InTech.(2012)
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‘Crystal structure of D-serine dehydratase from Escherichia coli’, Biochim Biophys Acta, 1824(3), 422–32, available: https://doi.org/10.1016/j.bbapap.2011.10.017.(2012)
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‘New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): Mutation within the GDF5 knuckle epitope causes noggin-resistance’, J Bone Miner Res, 27(2), 429–442, available: https://doi.org/10.1002/jbmr.532.(2012)
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‘Selecting highly structure-specific antibodies using structured synthetic mimics of the cystine knot protein sclerostin’, Protein Eng Des Sel, 25(5), 251–9, available: https://doi.org/10.1093/protein/gzs012.(2012)
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‘Enzymatic deglutathionylation to generate interleukin-4 cysteine muteins with free thiol’, Bioconjugate chemistry, 23(7), 1396–405, available: https://doi.org/10.1021/bc2004389.(2012)
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‘Promiscuity and specificity in BMP receptor activation’, FEBS letters, 586(14), 1846–59, available: https://doi.org/10.1016/j.febslet.2012.02.043.(2012)
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‘Salt stress triggers phosphorylation of the Arabidopsis vacuolar K+ channel TPK1 by calcium dependent protein kinases (CDPKs)’, Molecular Plant, 6(4), 1274–1289, available: https://doi.org/10.1093/mp/sss158.(2012)
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‘A substrate binding hinge domain is critical for transport-related structural changes of organic cation transporter 1’, J Biol Chem, 287(37), 31561–73, available: https://doi.org/10.1074/jbc.M112.388793.(2012)
2011[ to top ]
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‘Structure Analysis of the IL-5 Ligand-Receptor Complex Reveals a Wrench-like Architecture for IL-5Ralpha’, Structure, 19(12), 1864–75, available: https://doi.org/10.1016/j.str.2011.08.015.(2011)
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‘Purification, crystallization and preliminary data analysis of the ligand-receptor complex of the growth and differentiation factor 5 variant R57A (GDF5R57A) and BMP receptor IA (BRIA)’, Acta Cryst F, 67(Pt 5), 551–5, available: https://doi.org/10.1107/S1744309111006907.(2011)
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‘A novel calcium binding site in the slow vacuolar cation channel TPC1 senses luminal calcium levels’, Plant Cell, 23(7), 2696–707, available: https://doi.org/10.1105/tpc.111.086751.(2011)
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‘Gene expression profiling of connective tissue growth factor (CTGF) stimulated primary human tenon fibroblasts reveals an inflammatory and wound healing response in vitro’, Molecular Vision, 17, 53–62, available: http://www.ncbi.nlm.nih.gov/pubmed/21245951.(2011)
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‘Glycosylation of Twisted Gastrulation is Required for BMP Binding and Activity during Craniofacial Development’, Front Physiol, 2, 59, available: https://doi.org/10.3389/fphys.2011.00059.(2011)
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‘Single substitution within the RKTR motif impairs kinase activity but promotes dimerization of RAF kinase’, J Biol Chem, 286(18), 16491–503, available: https://doi.org/10.1074/jbc.M110.194167.(2011)
2010[ to top ]
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‘K+ transport characteristics of the plasma membrane tandem-pore channel TPK4 and pore chimeras with its vacuolar homologs’, FEBS Lett, 584(11), 2433–9, available: https://doi.org/10.1016/j.febslet.2010.04.038.(2010)
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‘Crystallization of BMP receptor type IA bound to the antibody Fab fragment AbD1556’, Acta Crystallogr Sect F Struct Biol Cryst Commun, 66(Pt 8), 964–8, available: https://doi.org/10.1107/S1744309110024681.(2010)
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‘Molecular basis of cytokine signalling--theme and variations’, FEBS J, 277(1), 106–18, available: https://doi.org/10.1111/j.1742-4658.2009.07480.x.(2010)
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‘First missense mutation in the SOST gene causing sclerosteosis by loss of sclerostin function’, Hum Mutat, 31(7), E1526–43, available: https://doi.org/10.1002/humu.21274.(2010)
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‘Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways’, J Biol Chem, 285(53), 41614–26, available: https://doi.org/10.1074/jbc.M110.153890.(2010)
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‘A selection fit mechanism in BMP receptor IA as a possible source for BMP ligand-receptor promiscuity’, PLoS One, 5(9), available: https://doi.org/10.1371/journal.pone.0013049.(2010)
2009[ to top ]
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‘Desmocollin 3-mediated Binding Is Crucial for Keratinocyte Cohesion and Is Impaired in Pemphigus’, Journal of Biological Chemistry, 284(44), 30556–30564, available: https://doi.org/10.1074/jbc.m109.024810.(2009)
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‘NMR structure of the Wnt modulator protein Sclerostin’, Biochem Biophys Res Commun, 380(1), 160–5, available: https://doi.org/10.1016/j.bbrc.2009.01.062.(2009)
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‘Charge-to-substrate ratio during organic cation uptake by rat OCT2 is voltage dependent and altered by exchange of glutamate 448 with glutamine’, Am J Physiol Renal Physiol, 296(4), F709–22, available: https://doi.org/10.1152/ajprenal.90323.2008.(2009)
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‘Peptides Targeting the Desmoglein 3 Adhesive Interface Prevent Autoantibody-induced Acantholysis in Pemphigus’, J Biol Chem, 284(13), 8589–95, available: https://doi.org/10.1074/jbc.M808813200.(2009)
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‘Purification, crystallization and preliminary data analysis of ligand-receptor complexes of growth and differentiation factor 5 (GDF5) and BMP receptor IB (BRIB)’, Acta Crystallogr Sect F Struct Biol Cryst Commun, 65(Pt 8), 779–83, available: https://doi.org/10.1107/S1744309109024142.(2009)