Bioinformatics | Small Non-coding RNAs

Research

My main subject of research are small non-coding RNAs.

In a current project I am studying the impact of piwi-interacting RNAs (piRNAs) on genome expansion in different lungfish species. Further I am interested in the involvement of piRNAs and miRNAs in the development of cancer. Another aspect of my research comprises genome-wide selection analyses to identify genes that might potentially be relevant for the adaptation to environmental conditions.

Keywords are the statistical and bioinformatical analysis of high throughput sequencing data, small non-coding RNAs, genome-wide selection analyses and the analysis of data resulting from different sequencing techniques from genomic as well as transcriptomic samples.

Members

Dr. Susanne Kneitz

Resaarch Associate

Lena Hahn

MD Student

Luca Münch

MD Student

Publications

 

 
Selected
Publications
 
 

 

Meyer et al.

 
Giant lungfish genome elucidates the conquest of land by vertebrates
 

Nature (2021)

Vardapour et al.

The DGCR8 E518K mutation found in Wilms tumors leads to a partial miRNA processing defect that alters gene expression patterns and biological processes

Carcinogenesis (2021)

Du et al.

 
The sterlet sturgeon genome sequence and the mechanisms of segmental rediploidization
 

Nat Ecol Evol (2020)

Jessen et al.

The transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression
 

Oncogene (2020)

Krebs et al.

miR-221-3p Regulates VEGFR2 Expression in High-Risk Prostate Cancer and Represents an Escape Mechanism from Sunitinib In Vitro

J Clin Med (2020)

Kneitz et al.

 
Germ cell and tumor associated piRNAs in the medaka and Xiphophorus melanoma models
 

BMC Genomics (2016)

 

 
Complete
Publication List