English
Lehrstuhl für Botanik I - Pflanzenphysiologie und Biophysik

Publikationen

Publikationen Prof. Thomas Müller

2024[ to top ]
  • Vaz, D.C., Rodrigues, J.R., Loureiro-Ferreira, N., Müller, T.D., Sebald, W., Redfield, C., und Brito, R.M.M. (2024) Lessons on protein structure from interleukin-4: All disulfides are not created equal, Proteins, 92(2), 219–235, verfügbar unter: https://doi.org/10.1002/prot.26611.
2023[ to top ]
  • Thomas, S., Fiebig, J.E., Kuhn, E.-M., Mayer, D.S., Filbeck, S., Schmitz, W., Krischke, M., Gropp, R., und Mueller, T.D. (2023) Design of Glycoengineered IL-4 Antagonists Employing Chemical and Biosynthetic Glycosylation, ACS omega, 8(28), 24841–24852, verfügbar unter: https://doi.org/10.1021/acsomega.3c00726.
  • Steiert, F., Schultz, P., Hoefinger, S., Mueller, T.D., Schwille, P., und Weidemann, T. (2023) Insights into receptor structure and dynamics at the surface of living cells, Nature Communications, 14(1596), 15, verfügbar unter: https://doi.org/doi: 10.1038/s41467-023-37284-4.
  • Hedrich, R., Müller, T.D., Marten, I., und Becker, D. (2023) TPC1 vacuole SV channel gains further shape – voltage priming of calcium-dependent gating, Trends in Plant Science, 28(6), 673–684, verfügbar unter: https://doi.org/https://doi.org/10.1016/j.tplants.2023.01.001.
  • Swinerd, G.W., Alhussini, A.A., Sczelecki, S., Heath, D., Mueller, T.D., McNatty, K.P., und Pitman, J.L. (2023) Molecular forms of BMP15 and GDF9 in mammalian species that differ in litter size, Scientific reports, 13(1), 22428–22428, verfügbar unter: https://doi.org/10.1038/s41598-023-49852-1.
2022[ to top ]
  • Siverino, C., Fahmy-Garcia, S., Mumcuoglu, D., Oberwinkler, H., Muehlemann, M., Mueller, T., Farrell, E., van Osch, G.J.V.M., und Nickel, J. (2022) Site-Directed Immobilization of an Engineered Bone Morphogenetic Protein 2 ({BMP}2) Variant to Collagen-Based Microspheres Induces Bone Formation In Vivo, International Journal of Molecular Sciences, 23(7), 3928, verfügbar unter: https://doi.org/10.3390/ijms23073928.
  • Bertho, S., Herpin, A., Jouanno, E., Yano, A., Bobe, J., Parrinello, H., Journot, L., Guyomard, R., Muller, T., Swanson, P., McKinney, G., Williamson, K., Meek, M., Schartl, M., und Guiguen, Y. (2022) A nonfunctional copy of the salmonid sex-determining gene (sdY) is responsible for the ‚apparent‘ XY females in Chinook salmon, Oncorhynchus tshawytscha, G3 (Bethesda, Md.), 12(2), jkab451-, verfügbar unter: https://doi.org/10.1093/g3journal/jkab451.
2021[ to top ]
  • Heinks, T., Hettwer, A., Hiepen, C., Weise, C., Gorka, M., Knaus, P., Mueller, T.D., und Loidl-Stahlhofen, A. (2021) Optimized expression and purification of a soluble BMP2 variant based on in-silico design, Protein Expression and Purification, 186, 105918, verfügbar unter: https://doi.org/https://doi.org/10.1016/j.pep.2021.105918.
  • Lehmann, J., Jørgensen, M.E., Fratz, S., Müller, H.M., Kusch, J., Scherzer, S., Navarro-Retamal, C., Mayer, D., Böhm, J., Konrad, K.R., Terpitz, U., Dreyer, I., Mueller, T.D., Sauer, M., Hedrich, R., Geiger, D., und Maierhofer, T. (2021) Acidosis-induced activation of anion channel SLAH3 in the flooding-related stress response of Arabidopsis, Current Biology, verfügbar unter: https://doi.org/https://doi.org/10.1016/j.cub.2021.06.018.
  • Imarazene, B., Du, K., Beille, S., Jouanno, E., Feron, R., Pan, Q., Torres-Paz, J., Lopez-Roques, C., Castinel, A., Gil, L., Kuchly, C., Donnadieu, C., Parrinello, H., Journot, L., Cabau, C., Zahm, M., Klopp, C., Pavlica, T., Al-Rikabi, A., Liehr, T., Simanovsky, S.A., Bohlen, J., Sember, A., Perez, J., Veyrunes, F., Mueller, T.D., Postlethwait, J.H., Schartl, M., Herpin, A., Rétaux, S., und Guiguen, Y. (2021) A supernumerary “B-sex” chromosome drives male sex determination in the Pachón cavefish, Astyanax mexicanus, Current Biology, 31(21), 4800–4809.e9, verfügbar unter: https://doi.org/https://doi.org/10.1016/j.cub.2021.08.030.
  • Lehmann, J., J{o}rgensen, M.E., Fratz, S., Müller, H.M., Kusch, J., Scherzer, S., Navarro-Retamal, C., Mayer, D., Böhm, J., Konrad, K.R., Terpitz, U., Dreyer, I., Mueller, T.D., Sauer, M., Hedrich, R., Geiger, D., und Maierhofer, T. (2021) Acidosis-induced activation of anion channel {SLAH}3 in the flooding-related stress response of Arabidopsis, Current Biology, 31(16), 3575–3585.e9, verfügbar unter: https://doi.org/10.1016/j.cub.2021.06.018.
2020[ to top ]
  • Lauffer, P., Miranda-Laferte, E., van Duyvenvoorde, H.A., van Haeringen, A., Werner, F., Boudin, E., Schmidt, H., Mueller, T.D., Kuhn, M., und van der Kaay, D.C.M. (2020) An Activating Deletion Variant in the Submembrane Region of Natriuretic Peptide Receptor-B Causes Tall Stature, J Clin Endocrinol Metab, 105(7), verfügbar unter: https://doi.org/10.1210/clinem/dgaa190.
  • Schinner, C., Erber, B.M., Yeruva, S., Schlipp, A., Rötzer, V., Kempf, E., Kant, S., Leube, R.E., Mueller, T.D., und Waschke, J. (2020) Stabilization of desmoglein-2 binding rescues arrhythmia in arrhythmogenic cardiomyopathy, {JCI} Insight, 5(9), verfügbar unter: https://doi.org/10.1172/jci.insight.130141.
  • Malinauskas, T., Peer, T.V., Bishop, B., Mueller, T.D., und Siebold, C. (2020) Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex, Proceedins of the National Academy of Sciences of the United States of America, 117(27), 15620–15631, verfügbar unter: https://doi.org/https://doi.org/10.1073/pnas.2000561117.
2019[ to top ]
  • Nickel, J. und Mueller, T.D. (2019) Specification of BMP Signaling, Cells, 8(12), verfügbar unter: https://doi.org/10.3390/cells8121579.
  • Vissing, J., Johnson, K., T{ö}pf, A., Nafissi, S., D{í}az-Manera, J., French, V.M., Schindler, R.F., Sarathchandra, P., Lokken, N., Rinn{é}, S., Freund, M., Decher, N., M{ü}ller, T., Duno, M., Krag, T., Brand, T., und Straub, V. (2019) POPDC3 Gene Variants Associate with a New Form of Limb Girdle Muscular Dystrophy, Ann Neurol, 86(6), 832–843, verfügbar unter: https://doi.org/10.1002/ana.25620.
  • Scheide-Noeth, J.P., Rosen, M., Baumstark, D., Dietz, H., und Mueller, T.D. (2019) Structural Basis of Interleukin-5 Inhibition by the Small Cyclic Peptide AF17121, J Mol Biol, 431(4), 714–731, verfügbar unter: https://doi.org/10.1016/j.jmb.2018.11.029.
  • Keller, T., Gorboulev, V., Mueller, T.D., D{ö}tsch, V., Bernhard, F., und Koepsell, H. (2019) Rat Organic Cation Transporter 1 Contains Three Binding Sites for Substrate 1-Methyl-4-phenylpyridinium per Monomer, Mol Pharmacol, 95(2), 169–182, verfügbar unter: https://doi.org/10.1124/mol.118.113498.
2018[ to top ]
  • Mumcuoglu, D., de Miguel, L., Jekhmane, S., Siverino, C., Nickel, J., Mueller, T.D., van Leeuwen, J.P., van Osch, G.J., und Kluijtmans, S.G. (2018) Collagen I derived recombinant protein microspheres as novel delivery vehicles for bone morphogenetic protein-2, Mater Sci Eng C Mater Biol Appl, 84, 271–280, verfügbar unter: https://doi.org/10.1016/j.msec.2017.11.031.
  • Nickel, J., Ten Dijke, P., und Mueller, T.D. (2018) TGF-β family co-receptor function and signaling, Acta Biochim Biophys Sin (Shanghai), 50(1), 12–36, verfügbar unter: https://doi.org/10.1093/abbs/gmx126.
  • Gorboulev, V., Rehman, S., Albert, C.M., Roth, U., Meyer, M.J., Tzvetkov, M.V., Mueller, T.D., und Koepsell, H. (2018) Assay Conditions Influence Affinities of Rat Organic Cation Transporter 1: Analysis of Mutagenesis in the Modeled Outward-facing Cleft by Measuring Effects of Substrates and Inhibitors on Initial Uptake, Mol Pharmacol, verfügbar unter: https://doi.org/10.1124/mol.117.110767.
  • Hedrich, R., Mueller, T.D., Becker, D., und Marten, I. (2018) Structure and Function of TPC1 Vacuole SV Channel Gains Shape, Mol Plant, verfügbar unter: https://doi.org/10.1016/j.molp.2018.03.017.
  • Siverino, C., Tabisz, B., L{ü}hmann, T., Meinel, L., M{ü}ller, T., Walles, H., und Nickel, J. (2018) Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry, J Vis Exp, (133), verfügbar unter: https://doi.org/10.3791/56616.
  • Braun, A.C., Gutmann, M., Mueller, T.D., L{ü}hmann, T., und Meinel, L. (2018) Bioresponsive release of insulin-like growth factor-I from its PEGylated conjugate, J Control Release, 279, 17–28, verfügbar unter: https://doi.org/10.1016/j.jconrel.2018.04.009.
  • Bertho, S., Herpin, A., Branthonne, A., Jouanno, E., Yano, A., Nicol, B., Muller, T., Pannetier, M., Pailhoux, E., Miwa, M., Yoshizaki, G., Schartl, M., und Guiguen, Y. (2018) The unusual rainbow trout sex determination gene hijacked the canonical vertebrate gonadal differentiation pathway, Proc Natl Acad Sci U S A, verfügbar unter: https://doi.org/10.1073/pnas.1803826115.
2017[ to top ]
  • Tabisz, B., Schmitz, W., Schmitz, M., Luehmann, T., Heusler, E., Rybak, J.C., Meinel, L., Fiebig, J.E., Mueller, T.D., und Nickel, J. (2017) Site-Directed Immobilization of BMP-2: Two Approaches for the Production of Innovative Osteoinductive Scaffolds, Biomacromolecules, 18(3), 695–708, verfügbar unter: https://doi.org/10.1021/acs.biomac.6b01407.
  • Silva-Vilches, C., Pletinckx, K., Lohnert, M., Pavlovic, V., Ashour, D., John, V., Vendelova, E., Kneitz, S., Zhou, J., Chen, R., Reinheckel, T., Mueller, T.D., Bodem, J., und Lutz, M.B. (2017) Low doses of cholera toxin and its mediator cAMP induce CTLA-2 secretion by dendritic cells to enhance regulatory T cell conversion, PLoS One, 12(7), verfügbar unter: https://doi.org/10.1371/journal.pone.0178114.
  • Lagler, C., El-Mesery, M., K{ü}bler, A.C., M{ü}ller-Richter, U.D.A., St{ü}hmer, T., Nickel, J., M{ü}ller, T.D., Wajant, H., und Seher, A. (2017) The anti-myeloma activity of bone morphogenetic protein 2 predominantly relies on the induction of growth arrest and is apoptosis-independent, PLoS One, 12(10), verfügbar unter: https://doi.org/10.1371/journal.pone.0185720.
  • Patino, L., Walton, K.L., Mueller, T., Johnson, K.E., Stocker, W., Richani, D., Agapiou, D., Gilchrist, R.B., Laissue, P., und Harrison, C.A. (2017) BMP15 Mutations Associated With Primary Ovarian Insufficiency Reduce Expression, Activity, or Synergy With GDF9, J Clin Endocrinol Metab, 102(3), 1009–1019.
  • Seher, A., Lagler, C., Stühmer, T., Müller-Richter, U.D.A., Kübler, A.C., Sebald, W., Müller, T.D., und Nickel, J. (2017) Utilizing BMP-2 muteins for treatment of multiple myeloma, PLOS ONE, 12(5), 1–18, verfügbar unter: https://doi.org/10.1371/journal.pone.0174884.
  • Richter, D., Moraga, I., Winkelmann, H., Birkholz, O., Wilmes, S., Schulte, M., Kraich, M., Kenneweg, H., Beutel, O., Selenschik, P., Paterok, D., Gavutis, M., Schmidt, T., Garcia, K.C., M{ü}ller, T.D., und Piehler, J. (2017) Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments, Nat Commun, 8, 15976–15976, verfügbar unter: https://doi.org/10.1038/ncomms15976.
  • Jodeleit, H., Palamides, P., Beigel, F., Mueller, T., Wolf, E., Siebeck, M., und Gropp, R. (2017) Design and validation of a disease network of inflammatory processes in the NSG-UC mouse model, J Transl Med, 15(1), 265–265, verfügbar unter: https://doi.org/10.1186/s12967-017-1368-4.
  • Lenglet, A., Jaślan, D., Toyota, M., Mueller, M., M{ü}ller, T., Sch{ö}nknecht, G., Marten, I., Gilroy, S., Hedrich, R., und Farmer, E.E. (2017) Control of basal jasmonate signalling and defence through modulation of intracellular cation flux capacity, New Phytol, 216(4), 1161–1169, verfügbar unter: https://doi.org/10.1111/nph.14754.
2016[ to top ]
  • Schindler, R.F., Scotton, C., Zhang, J., Passarelli, C., Ortiz-Bonnin, B., Simrick, S., Schwerte, T., Poon, K.L., Fang, M., Rinne, S., Froese, A., Nikolaev, V.O., Grunert, C., Muller, T., Tasca, G., Sarathchandra, P., Drago, F., Dallapiccola, B., Rapezzi, C., Arbustini, E., Di Raimo, F.R., Neri, M., Selvatici, R., Gualandi, F., Fattori, F., Pietrangelo, A., Li, W., Jiang, H., Xu, X., Bertini, E., Decher, N., Wang, J., Brand, T., und Ferlini, A. (2016) POPDC1(S201F) causes muscular dystrophy and arrhythmia by affecting protein trafficking, J Clin Invest, 126(1), 239–53, verfügbar unter: https://doi.org/10.1172/JCI79562.
  • Boschert, V., Frisch, C., Back, J.W., van Pee, K., Weidauer, S.E., Muth, E.M., Schmieder, P., Beerbaum, M., Knappik, A., Timmerman, P., und Mueller, T.D. (2016) The sclerostin-neutralizing antibody AbD09097 recognizes an epitope adjacent to sclerostin’s binding site for the Wnt co-receptor LRP6, Open Biol, 6(8), verfügbar unter: https://doi.org/10.1098/rsob.160120.
  • Bohm, J., Scherzer, S., Krol, E., Kreuzer, I., von Meyer, K., Lorey, C., Mueller, T.D., Shabala, L., Monte, I., Solano, R., Al-Rasheid, K.A., Rennenberg, H., Shabala, S., Neher, E., und Hedrich, R. (2016) The Venus Flytrap Dionaea muscipula Counts Prey-Induced Action Potentials to Induce Sodium Uptake, Curr Biol, 26(3), 286–95, verfügbar unter: https://doi.org/10.1016/j.cub.2015.11.057.
  • Jaslan, D., Mueller, T.D., Becker, D., Schultz, J., Cuin, T.A., Marten, I., Dreyer, I., Schonknecht, G., und Hedrich, R. (2016) Gating of the two-pore cation channel AtTPC1 in the plant vacuole is based on a single voltage-sensing domain, Plant Biol (Stuttg), 18(5), 750–60, verfügbar unter: https://doi.org/10.1111/plb.12478.
  • Hinck, A.P., Mueller, T.D., und Springer, T.A. (2016) Structural Biology and Evolution of the TGF-beta Family, Cold Spring Harb Perspect Biol, 8(12), verfügbar unter: https://doi.org/10.1101/cshperspect.a022103.
  • Yadin, D., Knaus, P., und Mueller, T.D. (2016) Structural insights into BMP receptors: Specificity, activation and inhibition, Cytokine Growth Factor Rev, 27, 13–34, verfügbar unter: https://doi.org/10.1016/j.cytogfr.2015.11.005.
  • Chintalapati, C., Keller, T., Mueller, T.D., Gorboulev, V., Schafer, N., Zilkowski, I., Veyhl-Wichmann, M., Geiger, D., Groll, J., und Koepsell, H. (2016) Protein RS1 (RSC1A1) Downregulates the Exocytotic Pathway of Glucose Transporter SGLT1 at Low Intracellular Glucose via Inhibition of Ornithine Decarboxylase, Mol Pharmacol, 90(5), 508–521, verfügbar unter: https://doi.org/10.1124/mol.116.104521.
  • Vendelova, E., Camargo de Lima, J., Lorenzatto, K.R., Monteiro, K.M., Mueller, T., Veepaschit, J., Grimm, C., Brehm, K., Hrckova, G., Lutz, M.B., Ferreira, H.B., und Nono, J.K. (2016) Proteomic Analysis of Excretory-Secretory Products of Mesocestoides corti Metacestodes Reveals Potential Suppressors of Dendritic Cell Functions, PLoS Negl Trop Dis, 10(10), e0005061, verfügbar unter: https://doi.org/10.1371/journal.pntd.0005061.
  • Palamides, P., Jodeleit, H., Fohlinger, M., Beigel, F., Herbach, N., Mueller, T., Wolf, E., Siebeck, M., und Gropp, R. (2016) A mouse model for ulcerative colitis based on NOD-scid IL2R gammanull mice reconstituted with peripheral blood mononuclear cells from affected individuals, Dis Model Mech, 9(9), 985–97, verfügbar unter: https://doi.org/10.1242/dmm.025452.
  • Deeken, R., Saupe, S., Klinkenberg, J., Riedel, M., Leide, J., Hedrich, R., und Mueller, T.D. (2016) The Nonspecific Lipid Transfer Protein AtLtpI-4 Is Involved in Suberin Formation of Arabidopsis thaliana Crown Galls, Plant Physiol, 172(3), 1911–1927, verfügbar unter: https://doi.org/10.1104/pp.16.01486.
  • Johnson, K.E., Makanji, Y., Temple-Smith, P., Kelly, E.K., Barton, P.A., Al-Musawi, S.L., Mueller, T.D., Walton, K.L., und Harrison, C.A. (2016) Biological activity and in vivo half-life of pro-activin A in male rats, Mol Cell Endocrinol, 422, 84–92, verfügbar unter: https://doi.org/10.1016/j.mce.2015.12.007.
  • Luhmann, T., Spieler, V., Werner, V., Ludwig, M.G., Fiebig, J., Mueller, T.D., und Meinel, L. (2016) Interleukin-4-Clicked Surfaces Drive M2 Macrophage Polarization, Chembiochem, 17(22), 2123–2128, verfügbar unter: https://doi.org/10.1002/cbic.201600480.
  • Bohm, J., Scherzer, S., Shabala, S., Krol, E., Neher, E., Mueller, T.D., und Hedrich, R. (2016) Venus Flytrap HKT1-Type Channel Provides for Prey Sodium Uptake into Carnivorous Plant Without Conflicting with Electrical Excitability, Mol Plant, 9(3), 428–36, verfügbar unter: https://doi.org/10.1016/j.molp.2015.09.017.
  • Chopra, M., Biehl, M., Steinfatt, T., Brandl, A., Kums, J., Amich, J., Vaeth, M., Kuen, J., Holtappels, R., Podlech, J., Mottok, A., Kraus, S., Jordan-Garrote, A.L., Bauerlein, C.A., Brede, C., Ribechini, E., Fick, A., Seher, A., Polz, J., Ottmuller, K.J., Baker, J., Nishikii, H., Ritz, M., Mattenheimer, K., Schwinn, S., Winter, T., Schafer, V., Krappmann, S., Einsele, H., Muller, T.D., Reddehase, M.J., Lutz, M.B., Mannel, D.N., Berberich-Siebelt, F., Wajant, H., und Beilhack, A. (2016) Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion, J Exp Med, 213(9), 1881–900, verfügbar unter: https://doi.org/10.1084/jem.20151563.
  • Paarmann, P., Dorpholz, G., Fiebig, J., Amsalem, A.R., Ehrlich, M., Henis, Y.I., Muller, T., und Knaus, P. (2016) Dynamin-dependent endocytosis of Bone Morphogenetic Protein2 (BMP2) and its receptors is dispensable for the initiation of Smad signaling, Int J Biochem Cell Biol, 76, 51–63, verfügbar unter: https://doi.org/10.1016/j.biocel.2016.04.010.
2015[ to top ]
  • Mueller, T.D. (2015) Mechanisms of BMP-Receptor Interaction and Activation, Vitam Horm, 99, 1–61, verfügbar unter: https://doi.org/10.1016/bs.vh.2015.06.003.
  • Mueller, T.D. (2015) RGM co-receptors add complexity to BMP signaling, Nat Struct Mol Biol, 22(6), 439–40, verfügbar unter: https://doi.org/10.1038/nsmb.3037.
  • Li, J.J., Sugimura, S., Mueller, T.D., White, M.A., Martin, G.A., Ritter, L.J., Liang, X.Y., Gilchrist, R.B., und Mottershead, D.G. (2015) Modifications of human growth differentiation factor 9 to improve the generation of embryos from low competence oocytes, Mol Endocrinol, 29(1), 40–52, verfügbar unter: https://doi.org/10.1210/me.2014-1173.
  • Paletta, D., Fichtner, A.S., Hahn, A.M., Starick, L., Beyersdorf, N., Monzon-Casanova, E., Mueller, T.D., und Herrmann, T. (2015) The hypervariable region 4 (HV4) and position 93 of the alpha chain modulate CD1d-glycolipid binding of iNKT TCRs, Eur J Immunol, 45(7), 2122–33, verfügbar unter: https://doi.org/10.1002/eji.201545534.
  • Mottershead, D.G., Sugimura, S., Al-Musawi, S.L., Li, J.J., Richani, D., White, M.A., Martin, G.A., Trotta, A.P., Ritter, L.J., Shi, J., Mueller, T.D., Harrison, C.A., und Gilchrist, R.B. (2015) Cumulin, an Oocyte-secreted Heterodimer of the Transforming Growth Factor-beta Family, Is a Potent Activator of Granulosa Cells and Improves Oocyte Quality, J Biol Chem, 290(39), 24007–20, verfügbar unter: https://doi.org/10.1074/jbc.M115.671487.
  • Stange, K., Desir, J., Kakar, N., Mueller, T.D., Budde, B.S., Gordon, C.T., Horn, D., Seemann, P., und Borck, G. (2015) A hypomorphic BMPR1B mutation causes du Pan acromesomelic dysplasia, Orphanet J Rare Dis, 10, 84, verfügbar unter: https://doi.org/10.1186/s13023-015-0299-5.
  • Bohm, J., Scherzer, S., Shabala, S., Krol, E., Neher, E., Mueller, T.D., und Hedrich, R. (2015) Venus Flytrap HKT1-Type Channel Provides for Prey Sodium Uptake into Carnivorous Plant Without Conflicting with Electrical Excitability, Mol Plant, verfügbar unter: https://doi.org/10.1016/j.molp.2015.09.017.
  • Boschert, V., Muth, E.M., Knappik, A., Frisch, C., und Mueller, T.D. (2015) Crystallization and preliminary X-ray crystallographic analysis of the sclerostin-neutralizing Fab AbD09097, Acta Crystallogr F Struct Biol Commun, 71(Pt 4), 388–92, verfügbar unter: https://doi.org/10.1107/S2053230X1500360X.
  • Klammert, U., Mueller, T.D., Hellmann, T.V., Wuerzler, K.K., Kotzsch, A., Schliermann, A., Schmitz, W., Kuebler, A.C., Sebald, W., und Nickel, J. (2015) GDF-5 can act as a context-dependent BMP-2 antagonist, BMC Biol, 13, 77, verfügbar unter: https://doi.org/10.1186/s12915-015-0183-8.
2014[ to top ]
  • Maierhofer, T., Lind, C., Huttl, S., Scherzer, S., Papenfuss, M., Simon, J., Al-Rasheid, K.A., Ache, P., Rennenberg, H., Hedrich, R., Muller, T.D., und Geiger, D. (2014) A Single-Pore Residue Renders the Arabidopsis Root Anion Channel SLAH2 Highly Nitrate Selective, Plant Cell, 26(6), 2554–2567, verfügbar unter: https://doi.org/10.1105/tpc.114.125849.
  • Tzvetkov, M.V., Seitz, T., Bokelmann, K., Mueller, T., Brockmoller, J., und Koepsell, H. (2014) Does the haplotype Met408-Del420, which was apparently predictive for imatinib efficacy, really exist and how strongly may it affect OCT1 activity?, Blood, 123(9), 1427–9, verfügbar unter: https://doi.org/10.1182/blood-2013-11-535864.
  • Duppatla, V., Gjorgjevikj, M., Schmitz, W., Hermanns, H.M., Schafer, C.M., Kottmair, M., Muller, T., und Sebald, W. (2014) IL-4 analogues with site-specific chemical modification at position 121 inhibit IL-4 and IL-13 biological activities, Bioconjugate chemistry, 25(1), 52–62, verfügbar unter: https://doi.org/10.1021/bc400307k.
  • Graul-Neumann, L.M., Deichsel, A., Wille, U., Kakar, N., Koll, R., Bassir, C., Ahmad, J., Cormier-Daire, V., Mundlos, S., Kubisch, C., Borck, G., Klopocki, E., Mueller, T.D., Doelken, S.C., und Seemann, P. (2014) Homozygous missense and nonsense mutations in BMPR1B cause acromesomelic chondrodysplasia-type Grebe, European journal of human genetics : EJHG, 22(6), 726–33, verfügbar unter: https://doi.org/10.1038/ejhg.2013.222.
2013[ to top ]
  • Laisney, J.A., Mueller, T.D., Schartl, M., und Meierjohann, S. (2013) Hyperactivation of constitutively dimerized oncogenic EGF receptors by autocrine loops, Oncogene, 32(19), 2403–11, verfügbar unter: https://doi.org/10.1038/onc.2012.267.
  • Nolte, T., Zadeh-Khorasani, M., Safarov, O., Rueff, F., Gulberg, V., Herbach, N., Wollenberg, A., Mueller, T., Siebeck, M., Wolf, E., und Gropp, R. (2013) Oxazolone and ethanol induce colitis in non-obese diabetic-severe combined immunodeficiency interleukin-2Rgamma(null) mice engrafted with human peripheral blood mononuclear cells, Clinical and experimental immunology, 172(2), 349–62, verfügbar unter: https://doi.org/10.1111/cei.12057.
  • Diestel, U., Resch, M., Meinhardt, K., Weiler, S., Hellmann, T.V., Mueller, T.D., Nickel, J., Eichler, J., und Muller, Y.A. (2013) Identification of a Novel TGF-beta-Binding Site in the Zona Pellucida C-terminal (ZP-C) Domain of TGF-beta-Receptor-3 (TGFR-3), PLoS One, 8(6), e67214, verfügbar unter: https://doi.org/10.1371/journal.pone.0067214.
  • van Dinther, M., Zhang, J., Weidauer, S.E., Boschert, V., Muth, E.M., Knappik, A., de Gorter, D.J., van Kasteren, P.B., Frisch, C., Mueller, T.D., und Ten Dijke, P. (2013) Anti-Sclerostin Antibody Inhibits Internalization of Sclerostin and Sclerostin-Mediated Antagonism of Wnt/LRP6 Signaling, PLoS One, 8(4), e62295, verfügbar unter: https://doi.org/10.1371/journal.pone.0062295.
  • Boschert, V., van Dinther, M., Weidauer, S., van Pee, K., Muth, E.M., Ten Dijke, P., und Mueller, T.D. (2013) Mutational analysis of sclerostin shows importance of the flexible loop and the cystine-knot for wnt-signaling inhibition, PLoS One, 8(11), e81710, verfügbar unter: https://doi.org/10.1371/journal.pone.0081710.
  • Nolte, T., Zadeh-Khorasani, M., Safarov, O., Rueff, F., Varga, R., Herbach, N., Wanke, R., Wollenberg, A., Mueller, T., Gropp, R., Wolf, E., und Siebeck, M. (2013) Induction of oxazolone-mediated features of atopic dermatitis in NOD-scid IL2Rgamma(null) mice engrafted with human peripheral blood mononuclear cells, Disease models & mechanisms, 6(1), 125–34, verfügbar unter: https://doi.org/10.1242/dmm.009167.
  • Fiebig, J.E., Weidauer, S.E., Qiu, L.Y., Bauer, M., Schmieder, P., Beerbaum, M., Zhang, J.L., Oschkinat, H., Sebald, W., und Mueller, T.D. (2013) The clip-segment of the von Willebrand domain 1 of the BMP modulator protein Crossveinless 2 is preformed, Molecules, 18(10), 11658–82, verfügbar unter: https://doi.org/10.3390/molecules181011658.
  • Mottershead, D.G., Harrison, C.A., Mueller, T.D., Stanton, P.G., Gilchrist, R.B., und McNatty, K.P. (2013) Growth differentiation factor 9:bone morphogenetic protein 15 (GDF9:BMP15) synergism and protein heterodimerization, Proceedings of the National Academy of Sciences of the United States of America, 110(25), E2257, verfügbar unter: https://doi.org/10.1073/pnas.1303459110.
  • Sibilski, C., Mueller, T., Kollipara, L., Zahedi, R.P., Rapp, U.R., Rudel, T., und Baljuls, A. (2013) Tyr728 in the kinase domain of the murine kinase suppressor of RAS 1 regulates binding and activation of the mitogen-activated protein kinase kinase, The Journal of biological chemistry, 288(49), 35237–52, verfügbar unter: https://doi.org/10.1074/jbc.M113.490235.
  • Hannema, S.E., van Duyvenvoorde, H.A., Premsler, T., Yang, R.B., Mueller, T.D., Gassner, B., Oberwinkler, H., Roelfsema, F., Santen, G.W., Prickett, T., Kant, S.G., Verkerk, A.J., Uitterlinden, A.G., Espiner, E., Ruivenkamp, C.A., Oostdijk, W., Pereira, A.M., Losekoot, M., Kuhn, M., und Wit, J.M. (2013) An activating mutation in the kinase homology domain of the natriuretic peptide receptor-2 causes extremely tall stature without skeletal deformities, The Journal of clinical endocrinology and metabolism, 98(12), E1988–98, verfügbar unter: https://doi.org/10.1210/jc.2013-2358.
  • Scherzer, S., Krol, E., Kreuzer, I., Kruse, J., Karl, F., von Ruden, M., Escalante-Perez, M., Muller, T., Rennenberg, H., Al-Rasheid, K.A., Neher, E., und Hedrich, R. (2013) The Dionaea muscipula Ammonium Channel DmAMT1 Provides NH4(+) Uptake Associated with Venus Flytrap’s Prey Digestion, Current biology : CB, 23(17), 1649–57, verfügbar unter: https://doi.org/10.1016/j.cub.2013.07.028.
  • Whitman, M., Rosen, V., Brivanlou, A.H., Groppe, J.C., Sebald, W., und Mueller, T. (2013) Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3, Nature medicine, 19(7), 809–10, verfügbar unter: https://doi.org/10.1038/nm.3080.
  • Zadeh-Khorasani, M., Nolte, T., Mueller, T.D., Pechlivanis, M., Rueff, F., Wollenberg, A., Fricker, G., Wolf, E., Siebeck, M., und Gropp, R. (2013) NOD-scid IL2R gammanull mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways, Journal of translational medicine, 11, 4, verfügbar unter: https://doi.org/10.1186/1479-5876-11-4.
2012[ to top ]
  • Duppatla, V., Gjorgjevikj, M., Schmitz, W., Kottmair, M., Mueller, T.D., und Sebald, W. (2012) Enzymatic deglutathionylation to generate interleukin-4 cysteine muteins with free thiol, Bioconjugate chemistry, 23(7), 1396–405, verfügbar unter: https://doi.org/10.1021/bc2004389.
  • Hellmann, T., Nickel, J., und Mueller, T. (2012) Missense mutations in GDF5 signaling: molecular mechanisms behind skeletal malformation, in Cooper, D. und Chen, J.-M., Hrsg., Gene Mutation, Rijeka, Croatia: InTech.
  • Schwaerzer, G.K., Hiepen, C., Schrewe, H., Nickel, J., Ploeger, F., Sebald, W., Mueller, T., und Knaus, P. (2012) New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): Mutation within the GDF5 knuckle epitope causes noggin-resistance, J Bone Miner Res, 27(2), 429–442, verfügbar unter: https://doi.org/10.1002/jbmr.532.
  • Urusova, D.V., Isupov, M.N., Antonyuk, S., Kachalova, G.S., Obmolova, G., Vagin, A.A., Lebedev, A.A., Burenkov, G.P., Dauter, Z., Bartunik, H.D., Lamzin, V.S., Melik-Adamyan, W.R., Mueller, T.D., und Schnackerz, K.D. (2012) Crystal structure of D-serine dehydratase from Escherichia coli, Biochim Biophys Acta, 1824(3), 422–32, verfügbar unter: https://doi.org/10.1016/j.bbapap.2011.10.017.
  • Back, J.W., Frisch, C., Van Pee, K., Boschert, V., van Vught, R., Puijk, W., Mueller, T.D., Knappik, A., und Timmerman, P. (2012) Selecting highly structure-specific antibodies using structured synthetic mimics of the cystine knot protein sclerostin, Protein Eng Des Sel, 25(5), 251–9, verfügbar unter: https://doi.org/10.1093/protein/gzs012.
  • Froese, A., Breher, S.S., Waldeyer, C., Schindler, R.F., Nikolaev, V.O., Rinne, S., Wischmeyer, E., Schlueter, J., Becher, J., Simrick, S., Vauti, F., Kuhtz, J., Meister, P., Kreissl, S., Torlopp, A., Liebig, S.K., Laakmann, S., Muller, T.D., Neumann, J., Stieber, J., Ludwig, A., Maier, S.K., Decher, N., Arnold, H.H., Kirchhof, P., Fabritz, L., und Brand, T. (2012) Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice, J Clin Invest, 122(3), 1119–30, verfügbar unter: https://doi.org/10.1172/JCI59410.
  • Egenberger, B., Gorboulev, V., Keller, T., Gorbunov, D., Gottlieb, N., Geiger, D., Mueller, T.D., und Koepsell, H. (2012) A substrate binding hinge domain is critical for transport-related structural changes of organic cation transporter 1, J Biol Chem, 287(37), 31561–73, verfügbar unter: https://doi.org/10.1074/jbc.M112.388793.
  • Mueller, T.D. und Nickel, J. (2012) Promiscuity and specificity in BMP receptor activation, FEBS letters, 586(14), 1846–59, verfügbar unter: https://doi.org/10.1016/j.febslet.2012.02.043.
  • Latz, A., Mehlmer, N., Zapf, S., Mueller, T.D., Wurzinger, B., Pfister, B., Csaszar, E., Hedrich, R., Teige, M., und Becker, D. (2012) Salt stress triggers phosphorylation of the Arabidopsis vacuolar K+ channel TPK1 by calcium dependent protein kinases (CDPKs), Molecular Plant, 6(4), 1274–1289, verfügbar unter: https://doi.org/10.1093/mp/sss158.
2011[ to top ]
  • Baljuls, A., Mahr, R., Schwarzenau, I., Muller, T., Polzien, L., Hekman, M., und Rapp, U.R. (2011) Single substitution within the RKTR motif impairs kinase activity but promotes dimerization of RAF kinase, J Biol Chem, 286(18), 16491–503, verfügbar unter: https://doi.org/10.1074/jbc.M110.194167.
  • {Billington, C.J., Fiebig, J.E., Forsman, C.L., Pham, L., Burbach, N., Sun, M., Jaskoll, T., Mansky, K., Gopalakrishnan, R., O’Connor, M.B., Mueller, T.D., und Petryk, A. (2011) Glycosylation of Twisted Gastrulation is Required for BMP Binding and Activity during Craniofacial Development, Front Physiol, 2, 59, verfügbar unter: https://doi.org/10.3389/fphys.2011.00059.
  • Patino, E., Kotzsch, A., Saremba, S., Nickel, J., Schmitz, W., Sebald, W., und Mueller, T.D. (2011) Structure Analysis of the IL-5 Ligand-Receptor Complex Reveals a Wrench-like Architecture for IL-5Ralpha, Structure, 19(12), 1864–75, verfügbar unter: https://doi.org/10.1016/j.str.2011.08.015.
  • Seher, A., Nickel, J., Mueller, T.D., Kneitz, S., Gebhardt, S., ter Vehn, T.M., Schlunck, G., und Sebald, W. (2011) Gene expression profiling of connective tissue growth factor (CTGF) stimulated primary human tenon fibroblasts reveals an inflammatory and wound healing response in vitro, Molecular Vision, 17, 53–62, verfügbar unter: http://www.ncbi.nlm.nih.gov/pubmed/21245951.
  • Dadacz-Narloch, B., Beyhl, D., Larisch, C., Lopez-Sanjurjo, E.J., Reski, R., Kuchitsu, K., Muller, T.D., Becker, D., Schonknecht, G., und Hedrich, R. (2011) A novel calcium binding site in the slow vacuolar cation channel TPC1 senses luminal calcium levels, Plant Cell, 23(7), 2696–707, verfügbar unter: https://doi.org/10.1105/tpc.111.086751.
  • Nickel, J., Kotzsch, A., Sebald, W., und Mueller, T.D. (2011) Purification, crystallization and preliminary data analysis of the ligand-receptor complex of the growth and differentiation factor 5 variant R57A (GDF5R57A) and BMP receptor IA (BRIA), Acta Cryst F, 67(Pt 5), 551–5, verfügbar unter: https://doi.org/10.1107/S1744309111006907.
2010[ to top ]
  • Harth, S., Kotzsch, A., Hu, J., Sebald, W., und Mueller, T.D. (2010) A selection fit mechanism in BMP receptor IA as a possible source for BMP ligand-receptor promiscuity, PLoS One, 5(9), verfügbar unter: https://doi.org/10.1371/journal.pone.0013049.
  • Sebald, W., Nickel, J., Zhang, J.L., und Mueller, T.D. (2010) Molecular basis of cytokine signalling--theme and variations, FEBS J, 277(1), 106–18, verfügbar unter: https://doi.org/10.1111/j.1742-4658.2009.07480.x.
  • Krause, C., Korchynskyi, O., de Rooij, K., Weidauer, S.E., de Gorter, D.J., van Bezooijen, R.L., Hatsell, S., Economides, A.N., Mueller, T.D., Lowik, C.W., und ten Dijke, P. (2010) Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways, J Biol Chem, 285(53), 41614–26, verfügbar unter: https://doi.org/10.1074/jbc.M110.153890.
  • Piters, E., Culha, C., Moester, M., Van Bezooijen, R., Adriaensen, D., Mueller, T., Weidauer, S., Jennes, K., de Freitas, F., Lowik, C., Timmermans, J.P., Van Hul, W., und Papapoulos, S. (2010) First missense mutation in the SOST gene causing sclerosteosis by loss of sclerostin function, Hum Mutat, 31(7), E1526–43, verfügbar unter: https://doi.org/10.1002/humu.21274.
  • Marcel, D., Muller, T., Hedrich, R., und Geiger, D. (2010) K+ transport characteristics of the plasma membrane tandem-pore channel TPK4 and pore chimeras with its vacuolar homologs, FEBS Lett, 584(11), 2433–9, verfügbar unter: https://doi.org/10.1016/j.febslet.2010.04.038.
  • Harth, S., Kotzsch, A., Sebald, W., und Mueller, T.D. (2010) Crystallization of BMP receptor type IA bound to the antibody Fab fragment AbD1556, Acta Crystallogr Sect F Struct Biol Cryst Commun, 66(Pt 8), 964–8, verfügbar unter: https://doi.org/10.1107/S1744309110024681.
2009[ to top ]
  • Heinecke, K., Seher, A., Schmitz, W., Mueller, T.D., Sebald, W., und Nickel, J. (2009) Receptor oligomerization and beyond: a case study in bone morphogenetic proteins, BMC Biol, 7, 59, verfügbar unter: https://doi.org/10.1186/1741-7007-7-59.
  • Spindler, V., Heupel, W.M., Efthymiadis, A., Schmidt, E., Eming, R., Rankl, C., Hinterdorfer, P., Muller, T., Drenckhahn, D., und Waschke, J. (2009) Desmocollin 3-mediated binding is crucial for keratinocyte cohesion and is impaired in pemphigus, J Biol Chem, 284(44), 30556–64, verfügbar unter: https://doi.org/10.1074/jbc.M109.024810.
  • Nickel, J., Sebald, W., Groppe, J.C., und Mueller, T.D. (2009) Intricacies of BMP receptor assembly, Cytokine Growth Factor Rev, 20(5-6), 367–77, verfügbar unter: https://doi.org/10.1016/j.cytogfr.2009.10.022.
  • Volk, C., Gorboulev, V., Kotzsch, A., Muller, T.D., und Koepsell, H. (2009) Five amino acids in the innermost cavity of the substrate binding cleft of organic cation transporter 1 interact with extracellular and intracellular corticosterone, Mol Pharmacol, 76(2), 275–89, verfügbar unter: https://doi.org/10.1124/mol.109.054783.
  • Heupel, W.M., Efthymiadis, A., Schlegel, N., Muller, T., Baumer, Y., Baumgartner, W., Drenckhahn, D., und Waschke, J. (2009) Endothelial barrier stabilization by a cyclic tandem peptide targeting VE-cadherin transinteraction in vitro and in vivo, J Cell Sci, 122(Pt 10), 1616–25, verfügbar unter: https://doi.org/10.1242/jcs.040212.
  • Kotzsch, A., Nickel, J., Seher, A., Sebald, W., und Muller, T.D. (2009) Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity, EMBO J, 28(7), 937–47, verfügbar unter: https://doi.org/10.1038/emboj.2009.37.
  • Kotzsch, A., Nickel, J., Sebald, W., und Mueller, T.D. (2009) Purification, crystallization and preliminary data analysis of ligand-receptor complexes of growth and differentiation factor 5 (GDF5) and BMP receptor IB (BRIB), Acta Crystallogr Sect F Struct Biol Cryst Commun, 65(Pt 8), 779–83, verfügbar unter: https://doi.org/10.1107/S1744309109024142.
  • Filatova, A., Leyerer, M., Gorboulev, V., Chintalapati, C., Reinders, Y., Muller, T.D., Srinivasan, A., Hubner, S., und Koepsell, H. (2009) Novel shuttling domain in a regulator (RSC1A1) of transporter SGLT1 steers cell cycle-dependent nuclear location, Traffic, 10(11), 1599–618, verfügbar unter: https://doi.org/10.1111/j.1600-0854.2009.00982.x.
  • Schmitt, B.M., Gorbunov, D., Schlachtbauer, P., Egenberger, B., Gorboulev, V., Wischmeyer, E., Muller, T., und Koepsell, H. (2009) Charge-to-substrate ratio during organic cation uptake by rat OCT2 is voltage dependent and altered by exchange of glutamate 448 with glutamine, Am J Physiol Renal Physiol, 296(4), F709–22, verfügbar unter: https://doi.org/10.1152/ajprenal.90323.2008.
  • Weidauer, S.E., Schmieder, P., Beerbaum, M., Schmitz, W., Oschkinat, H., und Mueller, T.D. (2009) NMR structure of the Wnt modulator protein Sclerostin, Biochem Biophys Res Commun, 380(1), 160–5, verfügbar unter: https://doi.org/10.1016/j.bbrc.2009.01.062.
  • Heupel, W.M., Muller, T., Efthymiadis, A., Schmidt, E., Drenckhahn, D., und Waschke, J. (2009) Peptides Targeting the Desmoglein 3 Adhesive Interface Prevent Autoantibody-induced Acantholysis in Pemphigus, J Biol Chem, 284(13), 8589–95, verfügbar unter: https://doi.org/10.1074/jbc.M808813200.
  • Spindler, V., Heupel, W.-M., Efthymiadis, A., Schmidt, E., Eming, R., Rankl, C., Hinterdorfer, P., Müller, T., Drenckhahn, D., und Waschke, J. (2009) Desmocollin 3-mediated Binding Is Crucial for Keratinocyte Cohesion and Is Impaired in Pemphigus, Journal of Biological Chemistry, 284(44), 30556–30564, verfügbar unter: https://doi.org/10.1074/jbc.m109.024810.
2008[ to top ]
  • Gorbunov, D., Gorboulev, V., Shatskaya, N., Mueller, T., Bamberg, E., Friedrich, T., und Koepsell, H. (2008) High-affinity cation binding to organic cation transporter 1 induces movement of helix 11 and blocks transport after mutations in a modeled interaction domain between two helices, Mol Pharmacol, 73(1), 50–61, verfügbar unter: https://doi.org/10.1124/mol.107.040170.
  • Baljuls, A., Schmitz, W., Mueller, T., Zahedi, R.P., Sickmann, A., Hekman, M., und Rapp, U.R. (2008) Positive regulation of A-RAF by phosphorylation of isoform-specific hinge segment and identification of novel phosphorylation sites, J Biol Chem, 283(40), 27239–54, verfügbar unter: https://doi.org/10.1074/jbc.M801782200.
  • Saremba, S., Nickel, J., Seher, A., Kotzsch, A., Sebald, W., und Mueller, T.D. (2008) Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand, FEBS J, 275(1), 172–83, verfügbar unter: https://doi.org/10.1111/j.1742-4658.2007.06187.x.
  • Hartmann, M., Skryabin, B.V., Muller, T., Gazinski, A., Schroter, J., Gassner, B., Nikolaev, V.O., Bunemann, M., und Kuhn, M. (2008) Alternative splicing of the guanylyl cyclase-A receptor modulates atrial natriuretic peptide signaling, J Biol Chem, 283(42), 28313–20, verfügbar unter: https://doi.org/10.1074/jbc.M805521200.
  • Dunkel, M., Latz, A., Schumacher, K., Muller, T., Becker, D., und Hedrich, R. (2008) Targeting of vacuolar membrane localized members of the TPK channel family, Mol Plant, 1(6), 938–49, verfügbar unter: https://doi.org/10.1093/mp/ssn064.
  • Kotzsch, A., Nickel, J., Seher, A., Heinecke, K., van Geersdaele, L., Herrmann, T., Sebald, W., und Mueller, T.D. (2008) Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome, J Biol Chem, 283(9), 5876–87, verfügbar unter: https://doi.org/10.1074/jbc.M706029200.
  • Qiu, L.Y., Zhang, J.L., Kotzsch, A., Sebald, W., und Mueller, T.D. (2008) Crystallization and preliminary X-ray analysis of the complex of the first von Willebrand type C domain bound to bone morphogenetic protein 2, Acta Crystallogr Sect F Struct Biol Cryst Commun, 64(Pt 4), 307–12, verfügbar unter: https://doi.org/10.1107/S1744309108006945.
  • Klages, J., Kotzsch, A., Coles, M., Sebald, W., Nickel, J., Muller, T., und Kessler, H. (2008) The solution structure of BMPR-IA reveals a local disorder-to-order transition upon BMP-2 binding, Biochemistry, 47(46), 11930–9, verfügbar unter: https://doi.org/10.1021/bi801059j.
  • Zhang, J.L., Qiu, L.Y., Kotzsch, A., Weidauer, S., Patterson, L., Hammerschmidt, M., Sebald, W., und Mueller, T.D. (2008) Crystal structure analysis reveals how the Chordin family member crossveinless 2 blocks BMP-2 receptor binding, Dev Cell, 14(5), 739–50, verfügbar unter: https://doi.org/10.1016/j.devcel.2008.02.017.
2007[ to top ]
  • Weber, D., Kotzsch, A., Nickel, J., Harth, S., Seher, A., Mueller, U., Sebald, W., und Mueller, T.D. (2007) A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor, BMC Struct Biol, 7, 6, verfügbar unter: https://doi.org/10.1186/1472-6807-7-6.
  • Sebald, W., Nickel, J., Seher, A., und Mueller, T. (2007) Bone morphogenetic proteins, in Baeuerlein, E., Epple, M., Behrens, P. und Pompe, W., Hrsg., Handbook of Biomineralization, Weinheim: Wiley-VCH Verlag GmbH Co. KGaA, 19–34.
  • Latz, A., Becker, D., Hekman, M., Muller, T., Beyhl, D., Marten, I., Eing, C., Fischer, A., Dunkel, M., Bertl, A., Rapp, U.R., und Hedrich, R. (2007) TPK1, a Ca(2+)-regulated Arabidopsis vacuole two-pore K(+) channel is activated by 14-3-3 proteins, Plant J, 52(3), 449–59, verfügbar unter: https://doi.org/10.1111/j.1365-313X.2007.03255.x.
  • Voss, K., Stahl, S., Schleider, E., Ullrich, S., Nickel, J., Mueller, T.D., und Felbor, U. (2007) CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations, Neurogenetics, 8(4), 249–56, verfügbar unter: https://doi.org/10.1007/s10048-007-0098-9.
  • Baljuls, A., Mueller, T., Drexler, H.C., Hekman, M., und Rapp, U.R. (2007) Unique N-region determines low basal activity and limited inducibility of A-RAF kinase: the role of N-region in the evolutionary divergence of RAF kinase function in vertebrates, J Biol Chem, 282(36), 26575–90, verfügbar unter: https://doi.org/10.1074/jbc.M702429200.
  • Mueller, T. und Sebald, W. (2007) Wie BMPs (bone morphogenetic proteins) ihre Rezeptoren binden und aktivieren, BIOspektrum, 3, 236–239.
  • Knackmuss, S., Krause, S., Engel, K., Reusch, U., Virchow, J.C., Mueller, T., Kraich, M., Little, M., Luttmann, W., und Friedrich, K. (2007) Specific inhibition of interleukin-13 activity by a recombinant human single-chain immunoglobulin domain directed against the IL-13 receptor alpha1 chain, Biol Chem, 388(3), 325–30, verfügbar unter: https://doi.org/10.1515/BC.2007.036.
2006[ to top ]
  • Meierjohann, S., Mueller, T., Schartl, M., und Buehner, M. (2006) A structural model of the extracellular domain of the oncogenic EGFR variant Xmrk, Zebrafish, 3(3), 359–69, verfügbar unter: https://doi.org/10.1089/zeb.2006.3.359.
  • Kraich, M., Klein, M., Patino, E., Harrer, H., Nickel, J., Sebald, W., und Mueller, T.D. (2006) A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor, BMC Biol, 4, 13, verfügbar unter: https://doi.org/10.1186/1741-7007-4-13.
2005[ to top ]
  • Stahl, S., Gaetzner, S., Mueller, T.D., und Felbor, U. (2005) Endostatin phenylalanines 31 and 34 define a receptor binding site, Genes Cells, 10(9), 929–39, verfügbar unter: https://doi.org/10.1111/j.1365-2443.2005.00890.x.
  • Popp, C., Gorboulev, V., Muller, T.D., Gorbunov, D., Shatskaya, N., und Koepsell, H. (2005) Amino acids critical for substrate affinity of rat organic cation transporter 1 line the substrate binding region in a model derived from the tertiary structure of lactose permease, Mol Pharmacol, 67(5), 1600–11, verfügbar unter: https://doi.org/10.1124/mol.104.008839.
  • Nickel, J., Kotzsch, A., Sebald, W., und Mueller, T.D. (2005) A single residue of GDF-5 defines binding specificity to BMP receptor IB, J Mol Biol, 349(5), 933–47, verfügbar unter: https://doi.org/10.1016/j.jmb.2005.04.015.
  • Mueller, T.D., Gottermeier, M., Sebald, W., und Nickel, J. (2005) Crystallization and preliminary X-ray diffraction analysis of human growth and differentiation factor 5 (GDF-5), Acta Crystallogr Sect F Struct Biol Cryst Commun, 61(Pt 1), 134–6, verfügbar unter: https://doi.org/10.1107/S1744309104031963.
2004[ to top ]
  • Mueller, T.D., Kamionka, M., und Feigon, J. (2004) Specificity of the interaction between ubiquitin-associated domains and ubiquitin, J Biol Chem, 279(12), 11926–36, verfügbar unter: https://doi.org/10.1074/jbc.M312865200.
  • Johansson, C., Finger, L.D., Trantirek, L., Mueller, T.D., Kim, S., Laird-Offringa, I.A., und Feigon, J. (2004) Solution structure of the complex formed by the two N-terminal RNA-binding domains of nucleolin and a pre-rRNA target, J Mol Biol, 337(4), 799–816, verfügbar unter: https://doi.org/10.1016/j.jmb.2004.01.056.
  • Sebald, W., Nickel, J., Zhang, J.L., und Mueller, T.D. (2004) Molecular recognition in bone morphogenetic protein (BMP)/receptor interaction, Biol Chem, 385(8), 697–710, verfügbar unter: https://doi.org/10.1515/BC.2004.086.
  • Keller, S., Nickel, J., Zhang, J.L., Sebald, W., und Mueller, T.D. (2004) Molecular recognition of BMP-2 and BMP receptor IA, Nat Struct Mol Biol, 11(5), 481–8, verfügbar unter: https://doi.org/10.1038/nsmb756.
2003[ to top ]
  • Sebald, W. und Mueller, T.D. (2003) The interaction of BMP-7 and ActRII implicates a new mode of receptor assembly, Trends Biochem Sci, 28(10), 518–21, verfügbar unter: https://doi.org/10.1016/j.tibs.2003.08.001.
  • Mueller, T.D. und Feigon, J. (2003) Structural determinants for the binding of ubiquitin-like domains to the proteasome, EMBO J, 22(18), 4634–45, verfügbar unter: https://doi.org/10.1093/emboj/cdg467.
2002[ to top ]
  • Mueller, T.D. und Feigon, J. (2002) Solution structures of UBA domains reveal a conserved hydrophobic surface for protein-protein interactions, J Mol Biol, 319(5), 1243–55, verfügbar unter: https://doi.org/10.1016/S0022-2836(02)00302-9.
  • Mueller, T.D., Zhang, J.L., Sebald, W., und Duschl, A. (2002) Structure, binding, and antagonists in the IL-4/IL-13 receptor system, Biochim Biophys Acta, 1592(3), 237–50, verfügbar unter: http://www.ncbi.nlm.nih.gov/pubmed/12421669.
2000[ to top ]
  • Withers-Ward, E.S., Mueller, T.D., Chen, I.S., und Feigon, J. (2000) Biochemical and structural analysis of the interaction between the UBA(2) domain of the DNA repair protein HHR23A and HIV-1 Vpr, Biochemistry, 39(46), 14103–12, verfügbar unter: http://www.ncbi.nlm.nih.gov/pubmed/11087358.
1997[ to top ]
  • Shaw, G.L., Muller, T., Campbell, I.D., Mott, H.R., Oschkinat, H., und Mitschang, L. (1997) Constant-time HQQC experiment for protein NMR spectroscopy, Journal of Magnetic Resonance, 124(2), 479–483, verfügbar unter: https://doi.org/Doi 10.1006/Jmre.1996.1062.
1995[ to top ]
  • Duschl, A., Muller, T., und Sebald, W. (1995) Antagonistic mutant proteins of interleukin-4, Behring Inst Mitt, (96), 87–94, verfügbar unter: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7575356.
  • Muller, T., Oehlenschlager, F., und Buehner, M. (1995) Human Interleukin-4 and Variant R88q - Phasing X-Ray-Diffraction Data by Molecular Replacement Using X-Ray and Nuclear-Magnetic-Resonance Models, Journal of Molecular Biology, 247(2), 360–372, verfügbar unter: https://doi.org/Doi 10.1006/Jmbi.1994.0144.
1994[ to top ]
  • Muller, T., Dieckmann, T., Sebald, W., und Oschkinat, H. (1994) Aspects of Receptor-Binding and Signaling of Interleukin-4 Investigated by Site-Directed Mutagenesis and Nmr-Spectroscopy, Journal of Molecular Biology, 237(4), 423–436, verfügbar unter: https://doi.org/Doi 10.1006/Jmbi.1994.1245.
  • Oschkinat, H., Muller, T., und Dieckmann, T. (1994) Protein-Structure Determination with 3-Dimensional and 4-Dimensional Nmr-Spectroscopy, Angewandte Chemie-International Edition in English, 33(3), 277–293, verfügbar unter: https://doi.org/Doi 10.1002/Anie.199402771.
  • Demchuk, E., Mueller, T., Oschkinat, H., Sebald, W., und Wade, R.C. (1994) Receptor-Binding Properties of 4-Helix-Bundle Growth-Factors Deduced from Electrostatic Analysis, Protein Science, 3(6), 920–935, verfügbar unter: /brokenurl#<Go to ISI>://WOS:A1994NN55000009.
  • Muller, T., Sebald, W., und Oschkinat, H. (1994) Antagonist Design through Forced Electrostatic Mismatch, Nature Structural Biology, 1(10), 674–676, verfügbar unter: https://doi.org/Doi 10.1038/Nsb1094-674.
1993[ to top ]
  • Kruse, N., Shen, B.J., Arnold, S., Tony, H.P., Muller, T., und Sebald, W. (1993) 2 Distinct Functional Sites of Human Interleukin-4 Are Identified by Variants Impaired in Either Receptor-Binding or Receptor Activation, Embo Journal, 12(13), 5121–5129, verfügbar unter: /brokenurl#<Go to ISI>://WOS:A1993MM12000024.