Publikationen
Publikationen Prof. Thomas Müller
- [ 2024 ]
- [ 2023 ]
- [ 2022 ]
- [ 2021 ]
- [ 2020 ]
- [ 2019 ]
- [ 2018 ]
- [ 2017 ]
- [ 2016 ]
- [ 2015 ]
- [ 2014 ]
- [ 2013 ]
- [ 2012 ]
- [ 2011 ]
- [ 2010 ]
- [ 2009 ]
- [ 2008 ]
- [ 2007 ]
- [ 2006 ]
- [ 2005 ]
- [ 2004 ]
- [ 2003 ]
- [ 2002 ]
- [ 2000 ]
- [ 1997 ]
- [ 1995 ]
- [ 1994 ]
- [ 1993 ]
2024[ to top ]
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„Lessons on protein structure from interleukin-4: All disulfides are not created equal“, Proteins, 92(2), 219–235, verfügbar unter: https://doi.org/10.1002/prot.26611.(2024)
2023[ to top ]
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„Design of Glycoengineered IL-4 Antagonists Employing Chemical and Biosynthetic Glycosylation“, ACS omega, 8(28), 24841–24852, verfügbar unter: https://doi.org/10.1021/acsomega.3c00726.(2023)
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„Insights into receptor structure and dynamics at the surface of living cells“, Nature Communications, 14(1596), 15, verfügbar unter: https://doi.org/doi: 10.1038/s41467-023-37284-4.(2023)
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„TPC1 vacuole SV channel gains further shape – voltage priming of calcium-dependent gating“, Trends in Plant Science, 28(6), 673–684, verfügbar unter: https://doi.org/https://doi.org/10.1016/j.tplants.2023.01.001.(2023)
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„Molecular forms of BMP15 and GDF9 in mammalian species that differ in litter size“, Scientific reports, 13(1), 22428–22428, verfügbar unter: https://doi.org/10.1038/s41598-023-49852-1.(2023)
2022[ to top ]
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„Site-Directed Immobilization of an Engineered Bone Morphogenetic Protein 2 ({BMP}2) Variant to Collagen-Based Microspheres Induces Bone Formation In Vivo“, International Journal of Molecular Sciences, 23(7), 3928, verfügbar unter: https://doi.org/10.3390/ijms23073928.(2022)
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„A nonfunctional copy of the salmonid sex-determining gene (sdY) is responsible for the ‚apparent‘ XY females in Chinook salmon, Oncorhynchus tshawytscha“, G3 (Bethesda, Md.), 12(2), jkab451-, verfügbar unter: https://doi.org/10.1093/g3journal/jkab451.(2022)
2021[ to top ]
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„A supernumerary “B-sex” chromosome drives male sex determination in the Pachón cavefish, Astyanax mexicanus“, Current Biology, 31(21), 4800–4809.e9, verfügbar unter: https://doi.org/https://doi.org/10.1016/j.cub.2021.08.030.(2021)
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„Acidosis-induced activation of anion channel SLAH3 in the flooding-related stress response of Arabidopsis“, Current Biology, verfügbar unter: https://doi.org/https://doi.org/10.1016/j.cub.2021.06.018.(2021)
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„Optimized expression and purification of a soluble BMP2 variant based on in-silico design“, Protein Expression and Purification, 186, 105918, verfügbar unter: https://doi.org/https://doi.org/10.1016/j.pep.2021.105918.(2021)
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„Acidosis-induced activation of anion channel {SLAH}3 in the flooding-related stress response of Arabidopsis“, Current Biology, 31(16), 3575–3585.e9, verfügbar unter: https://doi.org/10.1016/j.cub.2021.06.018.(2021)
2020[ to top ]
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„An Activating Deletion Variant in the Submembrane Region of Natriuretic Peptide Receptor-B Causes Tall Stature“, J Clin Endocrinol Metab, 105(7), verfügbar unter: https://doi.org/10.1210/clinem/dgaa190.(2020)
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„Stabilization of desmoglein-2 binding rescues arrhythmia in arrhythmogenic cardiomyopathy“, {JCI} Insight, 5(9), verfügbar unter: https://doi.org/10.1172/jci.insight.130141.(2020)
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„Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex“, Proceedins of the National Academy of Sciences of the United States of America, 117(27), 15620–15631, verfügbar unter: https://doi.org/https://doi.org/10.1073/pnas.2000561117.(2020)
2019[ to top ]
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„Specification of BMP Signaling“, Cells, 8(12), verfügbar unter: https://doi.org/10.3390/cells8121579.(2019)
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„POPDC3 Gene Variants Associate with a New Form of Limb Girdle Muscular Dystrophy“, Ann Neurol, 86(6), 832–843, verfügbar unter: https://doi.org/10.1002/ana.25620.(2019)
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„Structural Basis of Interleukin-5 Inhibition by the Small Cyclic Peptide AF17121“, J Mol Biol, 431(4), 714–731, verfügbar unter: https://doi.org/10.1016/j.jmb.2018.11.029.(2019)
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„Rat Organic Cation Transporter 1 Contains Three Binding Sites for Substrate 1-Methyl-4-phenylpyridinium per Monomer“, Mol Pharmacol, 95(2), 169–182, verfügbar unter: https://doi.org/10.1124/mol.118.113498.(2019)
2018[ to top ]
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„Collagen I derived recombinant protein microspheres as novel delivery vehicles for bone morphogenetic protein-2“, Mater Sci Eng C Mater Biol Appl, 84, 271–280, verfügbar unter: https://doi.org/10.1016/j.msec.2017.11.031.(2018)
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„TGF-β family co-receptor function and signaling“, Acta Biochim Biophys Sin (Shanghai), 50(1), 12–36, verfügbar unter: https://doi.org/10.1093/abbs/gmx126.(2018)
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„Assay Conditions Influence Affinities of Rat Organic Cation Transporter 1: Analysis of Mutagenesis in the Modeled Outward-facing Cleft by Measuring Effects of Substrates and Inhibitors on Initial Uptake“, Mol Pharmacol, verfügbar unter: https://doi.org/10.1124/mol.117.110767.(2018)
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„Structure and Function of TPC1 Vacuole SV Channel Gains Shape“, Mol Plant, verfügbar unter: https://doi.org/10.1016/j.molp.2018.03.017.(2018)
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„Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry“, J Vis Exp, (133), verfügbar unter: https://doi.org/10.3791/56616.(2018)
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„Bioresponsive release of insulin-like growth factor-I from its PEGylated conjugate“, J Control Release, 279, 17–28, verfügbar unter: https://doi.org/10.1016/j.jconrel.2018.04.009.(2018)
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„The unusual rainbow trout sex determination gene hijacked the canonical vertebrate gonadal differentiation pathway“, Proc Natl Acad Sci U S A, verfügbar unter: https://doi.org/10.1073/pnas.1803826115.(2018)
2017[ to top ]
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„Site-Directed Immobilization of BMP-2: Two Approaches for the Production of Innovative Osteoinductive Scaffolds“, Biomacromolecules, 18(3), 695–708, verfügbar unter: https://doi.org/10.1021/acs.biomac.6b01407.(2017)
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„Low doses of cholera toxin and its mediator cAMP induce CTLA-2 secretion by dendritic cells to enhance regulatory T cell conversion“, PLoS One, 12(7), verfügbar unter: https://doi.org/10.1371/journal.pone.0178114.(2017)
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„The anti-myeloma activity of bone morphogenetic protein 2 predominantly relies on the induction of growth arrest and is apoptosis-independent“, PLoS One, 12(10), verfügbar unter: https://doi.org/10.1371/journal.pone.0185720.(2017)
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„BMP15 Mutations Associated With Primary Ovarian Insufficiency Reduce Expression, Activity, or Synergy With GDF9“, J Clin Endocrinol Metab, 102(3), 1009–1019.(2017)
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„Utilizing BMP-2 muteins for treatment of multiple myeloma“, PLOS ONE, 12(5), 1–18, verfügbar unter: https://doi.org/10.1371/journal.pone.0174884.(2017)
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„Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments“, Nat Commun, 8, 15976–15976, verfügbar unter: https://doi.org/10.1038/ncomms15976.(2017)
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„Design and validation of a disease network of inflammatory processes in the NSG-UC mouse model“, J Transl Med, 15(1), 265–265, verfügbar unter: https://doi.org/10.1186/s12967-017-1368-4.(2017)
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„Control of basal jasmonate signalling and defence through modulation of intracellular cation flux capacity“, New Phytol, 216(4), 1161–1169, verfügbar unter: https://doi.org/10.1111/nph.14754.(2017)
2016[ to top ]
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„A mouse model for ulcerative colitis based on NOD-scid IL2R gammanull mice reconstituted with peripheral blood mononuclear cells from affected individuals“, Dis Model Mech, 9(9), 985–97, verfügbar unter: https://doi.org/10.1242/dmm.025452.(2016)
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„Gating of the two-pore cation channel AtTPC1 in the plant vacuole is based on a single voltage-sensing domain“, Plant Biol (Stuttg), 18(5), 750–60, verfügbar unter: https://doi.org/10.1111/plb.12478.(2016)
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„Structural Biology and Evolution of the TGF-beta Family“, Cold Spring Harb Perspect Biol, 8(12), verfügbar unter: https://doi.org/10.1101/cshperspect.a022103.(2016)
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„The sclerostin-neutralizing antibody AbD09097 recognizes an epitope adjacent to sclerostin’s binding site for the Wnt co-receptor LRP6“, Open Biol, 6(8), verfügbar unter: https://doi.org/10.1098/rsob.160120.(2016)
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„The Venus Flytrap Dionaea muscipula Counts Prey-Induced Action Potentials to Induce Sodium Uptake“, Curr Biol, 26(3), 286–95, verfügbar unter: https://doi.org/10.1016/j.cub.2015.11.057.(2016)
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„Structural insights into BMP receptors: Specificity, activation and inhibition“, Cytokine Growth Factor Rev, 27, 13–34, verfügbar unter: https://doi.org/10.1016/j.cytogfr.2015.11.005.(2016)
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„POPDC1(S201F) causes muscular dystrophy and arrhythmia by affecting protein trafficking“, J Clin Invest, 126(1), 239–53, verfügbar unter: https://doi.org/10.1172/JCI79562.(2016)
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„Proteomic Analysis of Excretory-Secretory Products of Mesocestoides corti Metacestodes Reveals Potential Suppressors of Dendritic Cell Functions“, PLoS Negl Trop Dis, 10(10), e0005061, verfügbar unter: https://doi.org/10.1371/journal.pntd.0005061.(2016)
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„Protein RS1 (RSC1A1) Downregulates the Exocytotic Pathway of Glucose Transporter SGLT1 at Low Intracellular Glucose via Inhibition of Ornithine Decarboxylase“, Mol Pharmacol, 90(5), 508–521, verfügbar unter: https://doi.org/10.1124/mol.116.104521.(2016)
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„Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion“, J Exp Med, 213(9), 1881–900, verfügbar unter: https://doi.org/10.1084/jem.20151563.(2016)
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„Interleukin-4-Clicked Surfaces Drive M2 Macrophage Polarization“, Chembiochem, 17(22), 2123–2128, verfügbar unter: https://doi.org/10.1002/cbic.201600480.(2016)
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„Venus Flytrap HKT1-Type Channel Provides for Prey Sodium Uptake into Carnivorous Plant Without Conflicting with Electrical Excitability“, Mol Plant, 9(3), 428–36, verfügbar unter: https://doi.org/10.1016/j.molp.2015.09.017.(2016)
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„The Nonspecific Lipid Transfer Protein AtLtpI-4 Is Involved in Suberin Formation of Arabidopsis thaliana Crown Galls“, Plant Physiol, 172(3), 1911–1927, verfügbar unter: https://doi.org/10.1104/pp.16.01486.(2016)
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„Biological activity and in vivo half-life of pro-activin A in male rats“, Mol Cell Endocrinol, 422, 84–92, verfügbar unter: https://doi.org/10.1016/j.mce.2015.12.007.(2016)
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„Dynamin-dependent endocytosis of Bone Morphogenetic Protein2 (BMP2) and its receptors is dispensable for the initiation of Smad signaling“, Int J Biochem Cell Biol, 76, 51–63, verfügbar unter: https://doi.org/10.1016/j.biocel.2016.04.010.(2016)
2015[ to top ]
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„Mechanisms of BMP-Receptor Interaction and Activation“, Vitam Horm, 99, 1–61, verfügbar unter: https://doi.org/10.1016/bs.vh.2015.06.003.(2015)
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„RGM co-receptors add complexity to BMP signaling“, Nat Struct Mol Biol, 22(6), 439–40, verfügbar unter: https://doi.org/10.1038/nsmb.3037.(2015)
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„The hypervariable region 4 (HV4) and position 93 of the alpha chain modulate CD1d-glycolipid binding of iNKT TCRs“, Eur J Immunol, 45(7), 2122–33, verfügbar unter: https://doi.org/10.1002/eji.201545534.(2015)
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„Modifications of human growth differentiation factor 9 to improve the generation of embryos from low competence oocytes“, Mol Endocrinol, 29(1), 40–52, verfügbar unter: https://doi.org/10.1210/me.2014-1173.(2015)
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„Cumulin, an Oocyte-secreted Heterodimer of the Transforming Growth Factor-beta Family, Is a Potent Activator of Granulosa Cells and Improves Oocyte Quality“, J Biol Chem, 290(39), 24007–20, verfügbar unter: https://doi.org/10.1074/jbc.M115.671487.(2015)
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„Venus Flytrap HKT1-Type Channel Provides for Prey Sodium Uptake into Carnivorous Plant Without Conflicting with Electrical Excitability“, Mol Plant, verfügbar unter: https://doi.org/10.1016/j.molp.2015.09.017.(2015)
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„A hypomorphic BMPR1B mutation causes du Pan acromesomelic dysplasia“, Orphanet J Rare Dis, 10, 84, verfügbar unter: https://doi.org/10.1186/s13023-015-0299-5.(2015)
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„Crystallization and preliminary X-ray crystallographic analysis of the sclerostin-neutralizing Fab AbD09097“, Acta Crystallogr F Struct Biol Commun, 71(Pt 4), 388–92, verfügbar unter: https://doi.org/10.1107/S2053230X1500360X.(2015)
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„GDF-5 can act as a context-dependent BMP-2 antagonist“, BMC Biol, 13, 77, verfügbar unter: https://doi.org/10.1186/s12915-015-0183-8.(2015)
2014[ to top ]
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„A Single-Pore Residue Renders the Arabidopsis Root Anion Channel SLAH2 Highly Nitrate Selective“, Plant Cell, 26(6), 2554–2567, verfügbar unter: https://doi.org/10.1105/tpc.114.125849.(2014)
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„IL-4 analogues with site-specific chemical modification at position 121 inhibit IL-4 and IL-13 biological activities“, Bioconjugate chemistry, 25(1), 52–62, verfügbar unter: https://doi.org/10.1021/bc400307k.(2014)
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„Does the haplotype Met408-Del420, which was apparently predictive for imatinib efficacy, really exist and how strongly may it affect OCT1 activity?“, Blood, 123(9), 1427–9, verfügbar unter: https://doi.org/10.1182/blood-2013-11-535864.(2014)
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„Homozygous missense and nonsense mutations in BMPR1B cause acromesomelic chondrodysplasia-type Grebe“, European journal of human genetics : EJHG, 22(6), 726–33, verfügbar unter: https://doi.org/10.1038/ejhg.2013.222.(2014)
2013[ to top ]
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„Mutational analysis of sclerostin shows importance of the flexible loop and the cystine-knot for wnt-signaling inhibition“, PLoS One, 8(11), e81710, verfügbar unter: https://doi.org/10.1371/journal.pone.0081710.(2013)
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„Oxazolone and ethanol induce colitis in non-obese diabetic-severe combined immunodeficiency interleukin-2Rgamma(null) mice engrafted with human peripheral blood mononuclear cells“, Clinical and experimental immunology, 172(2), 349–62, verfügbar unter: https://doi.org/10.1111/cei.12057.(2013)
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„Induction of oxazolone-mediated features of atopic dermatitis in NOD-scid IL2Rgamma(null) mice engrafted with human peripheral blood mononuclear cells“, Disease models & mechanisms, 6(1), 125–34, verfügbar unter: https://doi.org/10.1242/dmm.009167.(2013)
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„Anti-Sclerostin Antibody Inhibits Internalization of Sclerostin and Sclerostin-Mediated Antagonism of Wnt/LRP6 Signaling“, PLoS One, 8(4), e62295, verfügbar unter: https://doi.org/10.1371/journal.pone.0062295.(2013)
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„Hyperactivation of constitutively dimerized oncogenic EGF receptors by autocrine loops“, Oncogene, 32(19), 2403–11, verfügbar unter: https://doi.org/10.1038/onc.2012.267.(2013)
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„Identification of a Novel TGF-beta-Binding Site in the Zona Pellucida C-terminal (ZP-C) Domain of TGF-beta-Receptor-3 (TGFR-3)“, PLoS One, 8(6), e67214, verfügbar unter: https://doi.org/10.1371/journal.pone.0067214.(2013)
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„The clip-segment of the von Willebrand domain 1 of the BMP modulator protein Crossveinless 2 is preformed“, Molecules, 18(10), 11658–82, verfügbar unter: https://doi.org/10.3390/molecules181011658.(2013)
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„NOD-scid IL2R gammanull mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways“, Journal of translational medicine, 11, 4, verfügbar unter: https://doi.org/10.1186/1479-5876-11-4.(2013)
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„An activating mutation in the kinase homology domain of the natriuretic peptide receptor-2 causes extremely tall stature without skeletal deformities“, The Journal of clinical endocrinology and metabolism, 98(12), E1988–98, verfügbar unter: https://doi.org/10.1210/jc.2013-2358.(2013)
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„Tyr728 in the kinase domain of the murine kinase suppressor of RAS 1 regulates binding and activation of the mitogen-activated protein kinase kinase“, The Journal of biological chemistry, 288(49), 35237–52, verfügbar unter: https://doi.org/10.1074/jbc.M113.490235.(2013)
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„The Dionaea muscipula Ammonium Channel DmAMT1 Provides NH4(+) Uptake Associated with Venus Flytrap’s Prey Digestion“, Current biology : CB, 23(17), 1649–57, verfügbar unter: https://doi.org/10.1016/j.cub.2013.07.028.(2013)
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„Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3“, Nature medicine, 19(7), 809–10, verfügbar unter: https://doi.org/10.1038/nm.3080.(2013)
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„Growth differentiation factor 9:bone morphogenetic protein 15 (GDF9:BMP15) synergism and protein heterodimerization“, Proceedings of the National Academy of Sciences of the United States of America, 110(25), E2257, verfügbar unter: https://doi.org/10.1073/pnas.1303459110.(2013)
2012[ to top ]
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„Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice“, J Clin Invest, 122(3), 1119–30, verfügbar unter: https://doi.org/10.1172/JCI59410.(2012)
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„Missense mutations in GDF5 signaling: molecular mechanisms behind skeletal malformation“, in Cooper, D. und Chen, J.-M., Hrsg., Gene Mutation, Rijeka, Croatia: InTech.(2012)
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„Crystal structure of D-serine dehydratase from Escherichia coli“, Biochim Biophys Acta, 1824(3), 422–32, verfügbar unter: https://doi.org/10.1016/j.bbapap.2011.10.017.(2012)
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„New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): Mutation within the GDF5 knuckle epitope causes noggin-resistance“, J Bone Miner Res, 27(2), 429–442, verfügbar unter: https://doi.org/10.1002/jbmr.532.(2012)
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„Selecting highly structure-specific antibodies using structured synthetic mimics of the cystine knot protein sclerostin“, Protein Eng Des Sel, 25(5), 251–9, verfügbar unter: https://doi.org/10.1093/protein/gzs012.(2012)
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„Enzymatic deglutathionylation to generate interleukin-4 cysteine muteins with free thiol“, Bioconjugate chemistry, 23(7), 1396–405, verfügbar unter: https://doi.org/10.1021/bc2004389.(2012)
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„A substrate binding hinge domain is critical for transport-related structural changes of organic cation transporter 1“, J Biol Chem, 287(37), 31561–73, verfügbar unter: https://doi.org/10.1074/jbc.M112.388793.(2012)
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„Promiscuity and specificity in BMP receptor activation“, FEBS letters, 586(14), 1846–59, verfügbar unter: https://doi.org/10.1016/j.febslet.2012.02.043.(2012)
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„Salt stress triggers phosphorylation of the Arabidopsis vacuolar K+ channel TPK1 by calcium dependent protein kinases (CDPKs)“, Molecular Plant, 6(4), 1274–1289, verfügbar unter: https://doi.org/10.1093/mp/sss158.(2012)
2011[ to top ]
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„Glycosylation of Twisted Gastrulation is Required for BMP Binding and Activity during Craniofacial Development“, Front Physiol, 2, 59, verfügbar unter: https://doi.org/10.3389/fphys.2011.00059.(2011)
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„Single substitution within the RKTR motif impairs kinase activity but promotes dimerization of RAF kinase“, J Biol Chem, 286(18), 16491–503, verfügbar unter: https://doi.org/10.1074/jbc.M110.194167.(2011)
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„Structure Analysis of the IL-5 Ligand-Receptor Complex Reveals a Wrench-like Architecture for IL-5Ralpha“, Structure, 19(12), 1864–75, verfügbar unter: https://doi.org/10.1016/j.str.2011.08.015.(2011)
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„Gene expression profiling of connective tissue growth factor (CTGF) stimulated primary human tenon fibroblasts reveals an inflammatory and wound healing response in vitro“, Molecular Vision, 17, 53–62, verfügbar unter: http://www.ncbi.nlm.nih.gov/pubmed/21245951.(2011)
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„A novel calcium binding site in the slow vacuolar cation channel TPC1 senses luminal calcium levels“, Plant Cell, 23(7), 2696–707, verfügbar unter: https://doi.org/10.1105/tpc.111.086751.(2011)
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„Purification, crystallization and preliminary data analysis of the ligand-receptor complex of the growth and differentiation factor 5 variant R57A (GDF5R57A) and BMP receptor IA (BRIA)“, Acta Cryst F, 67(Pt 5), 551–5, verfügbar unter: https://doi.org/10.1107/S1744309111006907.(2011)
2010[ to top ]
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„Molecular basis of cytokine signalling--theme and variations“, FEBS J, 277(1), 106–18, verfügbar unter: https://doi.org/10.1111/j.1742-4658.2009.07480.x.(2010)
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„A selection fit mechanism in BMP receptor IA as a possible source for BMP ligand-receptor promiscuity“, PLoS One, 5(9), verfügbar unter: https://doi.org/10.1371/journal.pone.0013049.(2010)
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„Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways“, J Biol Chem, 285(53), 41614–26, verfügbar unter: https://doi.org/10.1074/jbc.M110.153890.(2010)
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„First missense mutation in the SOST gene causing sclerosteosis by loss of sclerostin function“, Hum Mutat, 31(7), E1526–43, verfügbar unter: https://doi.org/10.1002/humu.21274.(2010)
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„K+ transport characteristics of the plasma membrane tandem-pore channel TPK4 and pore chimeras with its vacuolar homologs“, FEBS Lett, 584(11), 2433–9, verfügbar unter: https://doi.org/10.1016/j.febslet.2010.04.038.(2010)
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„Crystallization of BMP receptor type IA bound to the antibody Fab fragment AbD1556“, Acta Crystallogr Sect F Struct Biol Cryst Commun, 66(Pt 8), 964–8, verfügbar unter: https://doi.org/10.1107/S1744309110024681.(2010)
2009[ to top ]
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„Endothelial barrier stabilization by a cyclic tandem peptide targeting VE-cadherin transinteraction in vitro and in vivo“, J Cell Sci, 122(Pt 10), 1616–25, verfügbar unter: https://doi.org/10.1242/jcs.040212.(2009)
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„Intricacies of BMP receptor assembly“, Cytokine Growth Factor Rev, 20(5-6), 367–77, verfügbar unter: https://doi.org/10.1016/j.cytogfr.2009.10.022.(2009)
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„Five amino acids in the innermost cavity of the substrate binding cleft of organic cation transporter 1 interact with extracellular and intracellular corticosterone“, Mol Pharmacol, 76(2), 275–89, verfügbar unter: https://doi.org/10.1124/mol.109.054783.(2009)
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„Desmocollin 3-mediated binding is crucial for keratinocyte cohesion and is impaired in pemphigus“, J Biol Chem, 284(44), 30556–64, verfügbar unter: https://doi.org/10.1074/jbc.M109.024810.(2009)
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„Receptor oligomerization and beyond: a case study in bone morphogenetic proteins“, BMC Biol, 7, 59, verfügbar unter: https://doi.org/10.1186/1741-7007-7-59.(2009)
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„Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity“, EMBO J, 28(7), 937–47, verfügbar unter: https://doi.org/10.1038/emboj.2009.37.(2009)
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„Novel shuttling domain in a regulator (RSC1A1) of transporter SGLT1 steers cell cycle-dependent nuclear location“, Traffic, 10(11), 1599–618, verfügbar unter: https://doi.org/10.1111/j.1600-0854.2009.00982.x.(2009)
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„Purification, crystallization and preliminary data analysis of ligand-receptor complexes of growth and differentiation factor 5 (GDF5) and BMP receptor IB (BRIB)“, Acta Crystallogr Sect F Struct Biol Cryst Commun, 65(Pt 8), 779–83, verfügbar unter: https://doi.org/10.1107/S1744309109024142.(2009)
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„Peptides Targeting the Desmoglein 3 Adhesive Interface Prevent Autoantibody-induced Acantholysis in Pemphigus“, J Biol Chem, 284(13), 8589–95, verfügbar unter: https://doi.org/10.1074/jbc.M808813200.(2009)
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„Charge-to-substrate ratio during organic cation uptake by rat OCT2 is voltage dependent and altered by exchange of glutamate 448 with glutamine“, Am J Physiol Renal Physiol, 296(4), F709–22, verfügbar unter: https://doi.org/10.1152/ajprenal.90323.2008.(2009)
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„NMR structure of the Wnt modulator protein Sclerostin“, Biochem Biophys Res Commun, 380(1), 160–5, verfügbar unter: https://doi.org/10.1016/j.bbrc.2009.01.062.(2009)
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„Desmocollin 3-mediated Binding Is Crucial for Keratinocyte Cohesion and Is Impaired in Pemphigus“, Journal of Biological Chemistry, 284(44), 30556–30564, verfügbar unter: https://doi.org/10.1074/jbc.m109.024810.(2009)
2008[ to top ]
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„High-affinity cation binding to organic cation transporter 1 induces movement of helix 11 and blocks transport after mutations in a modeled interaction domain between two helices“, Mol Pharmacol, 73(1), 50–61, verfügbar unter: https://doi.org/10.1124/mol.107.040170.(2008)
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„Alternative splicing of the guanylyl cyclase-A receptor modulates atrial natriuretic peptide signaling“, J Biol Chem, 283(42), 28313–20, verfügbar unter: https://doi.org/10.1074/jbc.M805521200.(2008)
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„Positive regulation of A-RAF by phosphorylation of isoform-specific hinge segment and identification of novel phosphorylation sites“, J Biol Chem, 283(40), 27239–54, verfügbar unter: https://doi.org/10.1074/jbc.M801782200.(2008)
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„Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand“, FEBS J, 275(1), 172–83, verfügbar unter: https://doi.org/10.1111/j.1742-4658.2007.06187.x.(2008)
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„Crystal structure analysis reveals how the Chordin family member crossveinless 2 blocks BMP-2 receptor binding“, Dev Cell, 14(5), 739–50, verfügbar unter: https://doi.org/10.1016/j.devcel.2008.02.017.(2008)
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„The solution structure of BMPR-IA reveals a local disorder-to-order transition upon BMP-2 binding“, Biochemistry, 47(46), 11930–9, verfügbar unter: https://doi.org/10.1021/bi801059j.(2008)
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„Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome“, J Biol Chem, 283(9), 5876–87, verfügbar unter: https://doi.org/10.1074/jbc.M706029200.(2008)
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„Crystallization and preliminary X-ray analysis of the complex of the first von Willebrand type C domain bound to bone morphogenetic protein 2“, Acta Crystallogr Sect F Struct Biol Cryst Commun, 64(Pt 4), 307–12, verfügbar unter: https://doi.org/10.1107/S1744309108006945.(2008)
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„Targeting of vacuolar membrane localized members of the TPK channel family“, Mol Plant, 1(6), 938–49, verfügbar unter: https://doi.org/10.1093/mp/ssn064.(2008)
2007[ to top ]
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„Bone morphogenetic proteins“, in Baeuerlein, E., Epple, M., Behrens, P. und Pompe, W., Hrsg., Handbook of Biomineralization, Weinheim: Wiley-VCH Verlag GmbH Co. KGaA, 19–34.(2007)
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„A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor“, BMC Struct Biol, 7, 6, verfügbar unter: https://doi.org/10.1186/1472-6807-7-6.(2007)
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„TPK1, a Ca(2+)-regulated Arabidopsis vacuole two-pore K(+) channel is activated by 14-3-3 proteins“, Plant J, 52(3), 449–59, verfügbar unter: https://doi.org/10.1111/j.1365-313X.2007.03255.x.(2007)
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„CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations“, Neurogenetics, 8(4), 249–56, verfügbar unter: https://doi.org/10.1007/s10048-007-0098-9.(2007)
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„Unique N-region determines low basal activity and limited inducibility of A-RAF kinase: the role of N-region in the evolutionary divergence of RAF kinase function in vertebrates“, J Biol Chem, 282(36), 26575–90, verfügbar unter: https://doi.org/10.1074/jbc.M702429200.(2007)
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„Wie BMPs (bone morphogenetic proteins) ihre Rezeptoren binden und aktivieren“, BIOspektrum, 3, 236–239.(2007)
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„Specific inhibition of interleukin-13 activity by a recombinant human single-chain immunoglobulin domain directed against the IL-13 receptor alpha1 chain“, Biol Chem, 388(3), 325–30, verfügbar unter: https://doi.org/10.1515/BC.2007.036.(2007)
2006[ to top ]
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„A structural model of the extracellular domain of the oncogenic EGFR variant Xmrk“, Zebrafish, 3(3), 359–69, verfügbar unter: https://doi.org/10.1089/zeb.2006.3.359.(2006)
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„A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor“, BMC Biol, 4, 13, verfügbar unter: https://doi.org/10.1186/1741-7007-4-13.(2006)
2005[ to top ]
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„Endostatin phenylalanines 31 and 34 define a receptor binding site“, Genes Cells, 10(9), 929–39, verfügbar unter: https://doi.org/10.1111/j.1365-2443.2005.00890.x.(2005)
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„Amino acids critical for substrate affinity of rat organic cation transporter 1 line the substrate binding region in a model derived from the tertiary structure of lactose permease“, Mol Pharmacol, 67(5), 1600–11, verfügbar unter: https://doi.org/10.1124/mol.104.008839.(2005)
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„A single residue of GDF-5 defines binding specificity to BMP receptor IB“, J Mol Biol, 349(5), 933–47, verfügbar unter: https://doi.org/10.1016/j.jmb.2005.04.015.(2005)
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„Crystallization and preliminary X-ray diffraction analysis of human growth and differentiation factor 5 (GDF-5)“, Acta Crystallogr Sect F Struct Biol Cryst Commun, 61(Pt 1), 134–6, verfügbar unter: https://doi.org/10.1107/S1744309104031963.(2005)
2004[ to top ]
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„Specificity of the interaction between ubiquitin-associated domains and ubiquitin“, J Biol Chem, 279(12), 11926–36, verfügbar unter: https://doi.org/10.1074/jbc.M312865200.(2004)
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„Molecular recognition in bone morphogenetic protein (BMP)/receptor interaction“, Biol Chem, 385(8), 697–710, verfügbar unter: https://doi.org/10.1515/BC.2004.086.(2004)
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„Solution structure of the complex formed by the two N-terminal RNA-binding domains of nucleolin and a pre-rRNA target“, J Mol Biol, 337(4), 799–816, verfügbar unter: https://doi.org/10.1016/j.jmb.2004.01.056.(2004)
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„Molecular recognition of BMP-2 and BMP receptor IA“, Nat Struct Mol Biol, 11(5), 481–8, verfügbar unter: https://doi.org/10.1038/nsmb756.(2004)
2003[ to top ]
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„The interaction of BMP-7 and ActRII implicates a new mode of receptor assembly“, Trends Biochem Sci, 28(10), 518–21, verfügbar unter: https://doi.org/10.1016/j.tibs.2003.08.001.(2003)
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„Structural determinants for the binding of ubiquitin-like domains to the proteasome“, EMBO J, 22(18), 4634–45, verfügbar unter: https://doi.org/10.1093/emboj/cdg467.(2003)
2002[ to top ]
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„Solution structures of UBA domains reveal a conserved hydrophobic surface for protein-protein interactions“, J Mol Biol, 319(5), 1243–55, verfügbar unter: https://doi.org/10.1016/S0022-2836(02)00302-9.(2002)
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„Structure, binding, and antagonists in the IL-4/IL-13 receptor system“, Biochim Biophys Acta, 1592(3), 237–50, verfügbar unter: http://www.ncbi.nlm.nih.gov/pubmed/12421669.(2002)
2000[ to top ]
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„Biochemical and structural analysis of the interaction between the UBA(2) domain of the DNA repair protein HHR23A and HIV-1 Vpr“, Biochemistry, 39(46), 14103–12, verfügbar unter: http://www.ncbi.nlm.nih.gov/pubmed/11087358.(2000)
1997[ to top ]
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1995[ to top ]
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„Human Interleukin-4 and Variant R88q - Phasing X-Ray-Diffraction Data by Molecular Replacement Using X-Ray and Nuclear-Magnetic-Resonance Models“, Journal of Molecular Biology, 247(2), 360–372, verfügbar unter: https://doi.org/Doi 10.1006/Jmbi.1994.0144.(1995)
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„Antagonistic mutant proteins of interleukin-4“, Behring Inst Mitt, (96), 87–94, verfügbar unter: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7575356.(1995)
1994[ to top ]
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„Aspects of Receptor-Binding and Signaling of Interleukin-4 Investigated by Site-Directed Mutagenesis and Nmr-Spectroscopy“, Journal of Molecular Biology, 237(4), 423–436, verfügbar unter: https://doi.org/Doi 10.1006/Jmbi.1994.1245.(1994)
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„Protein-Structure Determination with 3-Dimensional and 4-Dimensional Nmr-Spectroscopy“, Angewandte Chemie-International Edition in English, 33(3), 277–293, verfügbar unter: https://doi.org/Doi 10.1002/Anie.199402771.(1994)
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„Antagonist Design through Forced Electrostatic Mismatch“, Nature Structural Biology, 1(10), 674–676, verfügbar unter: https://doi.org/Doi 10.1038/Nsb1094-674.(1994)
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„Receptor-Binding Properties of 4-Helix-Bundle Growth-Factors Deduced from Electrostatic Analysis“, Protein Science, 3(6), 920–935, verfügbar unter: /brokenurl#<Go to ISI>://WOS:A1994NN55000009.(1994)
1993[ to top ]
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„2 Distinct Functional Sites of Human Interleukin-4 Are Identified by Variants Impaired in Either Receptor-Binding or Receptor Activation“, Embo Journal, 12(13), 5121–5129, verfügbar unter: /brokenurl#<Go to ISI>://WOS:A1993MM12000024.(1993)