AG Gaubatz | Publikationen
2024[ to top ]
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Inhibition of the YAP-MMB interaction and targeting NEK2 as potential therapeutic strategies for YAP-driven cancersOncogene, 43(8): 578–593.
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2023[ to top ]
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Oncogenic YAP mediates changes in chromatin accessibility and activity that drive cell cycle gene expression and cell migrationNucleic Acids Research. https://doi.org/10.1093/nar/gkad107.
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2022[ to top ]
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Expression of the cytokinesis regulator PRC1 results in p53-pathway activation in A549 cells but does not directly regulate gene expression in the nucleusCell Cycle, 22(4): 419–432.
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2021[ to top ]
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IQGAP3, a YAP Target, Is Required for Proper Cell-Cycle Progression and Genome StabilityMolecular Cancer Research, 19(10): 1712–1726.
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2020[ to top ]
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Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytesPLOS Genetics, 16(5): 1–27.
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2019[ to top ]
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The Myb-MuvB Complex Is Required for YAP-Dependent Transcription of Mitotic GenesCell Reports, 27(12): 3533 – 3546.e7.
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One way to rule them all: G2/M gene regulation by oncogenic YAP1 and B-MYBMolecular \& Cellular Oncology, 6(6): e1648026.
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2017[ to top ]
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The microtubule-associated protein PRC1 is a potential therapeutic target for lung cancerOncotarget, 9(4): 4985–4997.
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Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during developmentProceedings of the National Academy of Sciences, 114(30): 8029–8034.
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Central spindle proteins and mitotic kinesins are direct transcriptional targets of MuvB, B-MYB and FOXM1 in breast cancer cell lines and are potential targets for therapyOncotarget, 8(7): 11160–11172.
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GAS2L3: Coordinator of cardiomyocyte cytokinesis?Cell Cycle, 16(20): 1853–1854.
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2016[ to top ]
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An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinomaOncogene, 36(1): 110–121.
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2014[ to top ]
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Induction of p21CIP1 Protein and Cell Cycle Arrest after Inhibition of Aurora B Kinase Is Attributed to Aneuploidy and Reactive Oxygen SpeciesJournal of Biological Chemistry, 289(23): 16072–16084.
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The GAR domain of GAS2L3 mediates binding to the chromosomal passenger complex and is required for localization of GAS2L3 to the constriction zone during abscissionFEBS Journal, 281(9): 2123–2135.
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2013[ to top ]
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A role for p38 in transcriptional elongation of p21(CIP) in response to Aurora B inhibitionCell Cycle, 12(13): 2051–2060.
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LIN9, a Subunit of the DREAM Complex, Regulates Mitotic Gene Expression and Proliferation of Embryonic Stem CellsPLOS ONE, 8(5): 1–14.
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2012[ to top ]
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GAS2L3, a novel target gene of the dream complex, is required for proper cytokinesis and genomic stabilityJournal of Cell Science. https://doi.org/10.1242/jcs.097253.
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2011[ to top ]
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An intact retinoblastoma protein-binding site in Merkel cell polyomavirus large T antigen is required for promoting growth of Merkel cell carcinoma cellsInternational Journal of Cancer, 130(4): 847–856.
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Loss of LIN9, a member of the DREAM complex, cooperates with SV40 large T antigen to induce genomic instability and anchorage-independent growthOncogene, 31(14): 1859–1868.
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2010[ to top ]
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Lin9, a Subunit of the Mammalian DREAM Complex, Is Essential for Embryonic Development, for Survival of Adult Mice, and for Tumor SuppressionMolecular and Cellular Biology, 30(12): 2896–2908.
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MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferationMolecular Cancer, 9(1): 201-.
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2009[ to top ]
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B-MYB Is Required for Recovery from the DNA Damage\textendashInduced G2 Checkpoint in p53 Mutant CellsCancer Research, 69(9): 4073–4080.
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LIN54 is an essential core subunit of the DREAM/LINC complex that binds to the cdc2 promoter in a sequence‐specific mannerThe FEBS Journal, 276(19): 5703–5716.
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lin9 Is Required for Mitosis and Cell Survival during Early Zebrafish DevelopmentJournal of Biological Chemistry, 284(19): 13119–13127.
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2008[ to top ]
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A Conserved E2F6-Binding Element in Murine Meiosis-Specific Gene PromotersBiology of Reproduction, 79(5): 921–930.
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2007[ to top ]
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LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genesCell Cycle, 6(15): 1903–1913.
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2006[ to top ]
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The human synMuv-like protein LIN-9 is required for transcription of G2/M genes and for entry into mitosisThe EMBO Journal, 26(1): 144–157.
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2005[ to top ]
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Silencing of the Meiotic Genes SMC1β and STAG3 in Somatic Cells by E2F6Journal of Biological Chemistry, 280(50): 41380–41386.
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2004[ to top ]
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A role for E2F6 in distinguishing G1/S- and G2/M-specific transcriptionGenes &Amp; Development, 18(23, /content/18/23.cover.gif): 2941–2951.
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Inhibition of oncogenic transformation by mammalian Lin-9, a pRB-associated proteinThe EMBO Journal, 23(23): 4627–4638.
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2003[ to top ]
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Epstein-Barr virus LMP1 blocks p16INK4a\textendashRB pathway by promoting nuclear export of E2F4/5Journal of Cell Biology, 162(2): 173–183.
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2002[ to top ]
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A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cellsScience, 296(5570): 1132–1136.
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Two different E2F6 proteins generated by alternative splicing and internal translation initiationEur J Biochem, 269(20): 5030–5036.
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Homeotic transformations of the axial skeleton that accompany a targeted deletion of E2F6EMBO Reports, 3: 695–700.
2001[ to top ]
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E2F4 is exported from the nucleus in a CRM1-dependent mannerMol Cell Biol, 21(4): 1384–1392.
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2000[ to top ]
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E2F4 and E2F5 play an essential role in pocket protein-mediated G1 controlMol Cell, 6(3): 729–735.
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1999[ to top ]
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Bin1 functionally interacts with Myc and inhibits cell proliferation via multiple mechanismsOncogene, 18(24): 3564–3573.
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1998[ to top ]
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Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6Proc Natl Acad Sci USA, 95(16): 9190–9195.
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A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targetingGenes Dev, 12(8): 1092–1098.
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1997[ to top ]
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The subcellular localization of E2F-4 is cell-cycle dependentProc Natl Acad Sci U S A, 94(10): 5095–5100.
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1996[ to top ]
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Discrimination between different E-box-binding proteins at an endogenous target gene of c-mycGenes Dev, 10(4): 447–460.
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1995[ to top ]
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Transcriptional activation by Myc is under negative control by the transcription factor AP-2EMBO J, 14(7): 1508–1519.
1994[ to top ]
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An E-box element localized in the first intron mediates regulation of the prothymosin alpha gene by c-mycMol Cell Biol, 14(6): 3853–3862.
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1992[ to top ]
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The combination of dissimilar alleles of the A alpha and A beta gene complexes, whose proteins contain homeo domain motifs, determines sexual development in the mushroom Coprinus cinereusGenes Dev, 6(4): 568–577.
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